INCREASED VITAL AND TOTAL LUNG CAPACITIES IN TIBETAN COMPARED TO HAN RESIDENTS OF LHASA (3,658 M)
INCREASED VITAL AND TOTAL LUNG CAPACITIES IN TIBETAN COMPARED TO HAN RESIDENTS OF LHASA (3,658 M)
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DOI：
10.1002/ajpa.1330860303
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发表时间：
1991-11-01
影响因子：
2.8
通讯作者：
MOORE, LG
中科院分区：
文献类型：
--
作者：
DROMA, T;MCCULLOUGH, RG;MOORE, LG
据报道，与海平面居民相比，安第斯高海拔居民的胸部尺寸和肺容量更大，这与提高肺弥散能力有关。在尼泊尔进行的研究表明，终身居住在喜马拉雅山的人胸部尺寸并没有扩大。为了确定高海拔喜马拉雅人（藏族人）是否比适应新环境的人（汉族“中国人”）具有更大的肺容量，我们研究了中国西藏自治区拉萨（海拔3，658米）的38名藏族和43名汉族居民，他们的年龄，身高，体重和吸烟史相匹配。与汉族受试者相比，藏族受试者的总肺活量较大[6.80 ± 0.19（平均值+/- SEM）vs 6.24 +/- 0.18 1 BTPS，P < 0.05]，肺活量（5.00 +/- 0.08 vs 4.51 +/- 0.10 1 BTPS，P < 0.05），并倾向于具有更大的残余量（1.86 +/- 0.12 vs 1.56 +/- 0.09 1 BTPS，P < 0.06）。藏族胸围大于汉族（85 +/- 1 vs 82 +/- 1 cm，P < 0.05），且与肺活量相关（r = 0.69，P <0.05）。05）。汉族迁移到高海拔地区的儿童（小于或等于5岁，n = 6）相比，汉族成年移民（大于或等于18岁，n = 26）更短，但有相似的肺体积和容量时，身体大小标准化。西藏人的肺活量和总肺活量与身体大小的关系与以前报道的南美和北美高海拔地区终身居民的数值相似。因此，藏人与北美和南美的高海拔居民一样，有更大的肺容量。这可能是重要的，以提高肺弥散能力和保持动脉血氧饱和度在运动过程中。
Larger chest dimensions and lung volumes have been reported for Andean high-altitude natives compared with sea-level residents and implicated in raising lung diffusing capacity. Studies conducted in Nepal suggested that lifelong Himalayan residents did not have enlarged chest dimensions. To determine if high-altitude Himalayans (Tibetans) had larger lung volumes than acclimatized newcomers (Han "Chinese"), we studied 38 Tibetan and 43 Han residents of Lhasa, Tibet Autonomous Region, China (elevation 3,658 m) matched for age, height, weight, and smoking history. The Tibetan compared with the Han subjects had a larger total lung capacity [6.80 +/- 0.19 (mean +/- SEM) vs 6.24 +/- 0.18 1 BTPS, P < 0.05], vital capacity (5.00 +/- 0.08 vs 4.51 +/- 0.10 1 BTPS, P < 0.05), and tended to have a greater residual volume (1.86 +/- 0.12 vs 1.56 +/- 0.09 1 BTPS, P < 0.06). Chest circumference was greater in the Tibetan than the Han subjects (85 +/- 1 vs 82 +/- 1 cm, P < 0.05) and correlated with vital capacity in each group as well as in the two groups combined (r = 0.69, P < 0. 05). Han who had migrated to high altitude as children (less-than-or-equal-to 5 years old, n = 6) compared to Han adult migrants (greater-than-or-equal-to 18 years old, n = 26) were shorter but had similar lung volumes and capacities when normalized for body size. The Tibetans' vital capacity and total lung capacity in relation to body size were similar to values reported previously for lifelong residents of high altitude in South and North America. Thus, Tibetans, like North and South American high-altitude residents, have larger lung volumes. This may be important for raising lung diffusing capacity and preserving arterial oxygen saturation during exercise.