Exploring novel functions of BACH2 in the acquisition of antigen-specific antibodies
Exploring novel functions of BACH2 in the acquisition of antigen-specific antibodies
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探索 BACH2 在抗原特异性抗体获取中的新功能
DOI：
10.1093/intimm/dxac065
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发表时间：
2022
影响因子：
4.4
通讯作者：
Kazuhiko Igarashi
中科院分区：
文献类型：
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作者：
Kyoko Ochiai ; Kazuhiko Igarashi
BACH 2 [BTB（broad-complex，tramtrak and bric à brac）and CNC（cap 'n' collar）homolog 2]被认为是一种转录抑制因子，在调节免疫细胞分化中发挥广泛作用。在这里，我们专注于BACH 2在B细胞中的功能，其中BACH 2首次被证明在免疫系统中发挥重要作用。在B细胞中，BACH 2协调基因调控网络，促进抗体的类别转换和亲和力成熟，同时抑制浆细胞分化。在这种情况下，BACH 2通过调节染色质组织来调节基因表达，分别与其他转录因子和染色质调节因子如IRF 4（干扰素调节因子4）和PC 4（阳性共激活因子4）合作。此外，我们最近的观察提出了BACH 2具有多种功能的可能性，例如基因激活。由于BACH 2的功能障碍导致人类免疫缺陷的发生，揭示BACH 2的新功能可能会为解决BACH 2如何有助于预防这些疾病提供线索。
BACH2 [BTB (broad-complex, tramtrak and bric à brac) and CNC (cap ‘n’ collar) homolog 2] is known as a transcriptional repressor and broadly functions in regulating immune cell differentiation. Here, we focus on BACH2 function in B cells, where BACH2 was first shown to play an important role in the immune system. In B cells, BACH2 orchestrates the gene regulatory network that promotes class switch and affinity maturation of antibodies and simultaneously represses plasma-cell differentiation. In this context, BACH2 regulates gene expression by modulating chromatin organization, cooperatively with other transcription factors and chromatin regulators, such as IRF4 (interferon regulatory factor 4) and PC4 (positive coactivator 4), respectively. In addition, our recent observation raises the possibility that BACH2 has diverse functions, such as those in gene activation. Since dysfunction of BACH2 leads to the onset of human immune deficiencies, revealing new functions of BACH2 may give a cue to solve how BACH2 contributes to preventing these diseases.