Entamoeba histolytica:: Computational identification of putative microRNA candidates
Entamoeba histolytica:: Computational identification of putative microRNA candidates
复制标题
DOI：
10.1016/j.exppara.2006.01.009
复制
发表时间：
2006-08-01
影响因子：
2.1
通讯作者：
Ghosh, Sudip K.
中科院分区：
文献类型：
--
作者：
De, Subhajyoti;Pal, Dibyarupa;Ghosh, Sudip K.
MicroRNA 是一类丰富的类似于 20-24 核苷酸非编码 RNA，可在转录后水平控制多个基因的表达，调节多个重要的生化途径。 MicroRNA 已在包括人类在内的许多脊椎动物中被发现，也在苍蝇、线虫、植物和病毒中被发现。在目前的工作中，我们使用生物信息学方法鉴定了致病性寄生虫溶组织内阿米巴中的 17 个假定的候选 microRNA。溶组织内阿米巴中假定的 microRNA 鉴定可以作为内阿米巴基因组中 miRNA 克隆和表征的起始参考。 (c) 2006 Elsevier Inc. 保留所有权利。
MicroRNAs are an abundant class of similar to 20-24-nucleotide noncoding RNAs that control the expression of several genes at the posttranscriptional level, regulating several important biochemical pathways. MicroRNAs have been identified in many vertebrates including humans, and also in flies, nematodes, plants, and viruses. In the present work we have identified seventeen putative candidate microRNAs in the pathogenic parasite Entamoeba histolytica using a bioinformatic approach. Putative microRNA identification in E histolytica may act as a starting reference for cloning and characterization of miRNAs in Entamoeba genome. (c) 2006 Elsevier Inc. All rights reserved.