Long-Chain Omega-3 Fatty Acids and Women's Mental Health in the Perinatal Period and Beyond
Long-Chain Omega-3 Fatty Acids and Women's Mental Health in the Perinatal Period and Beyond
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DOI：
10.1016/j.jmwh.2010.02.014
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发表时间：
2010-11-01
影响因子：
2.7
通讯作者：
Kendall-Tackett, Kathleen
中科院分区：
文献类型：
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作者：
Kendall-Tackett, Kathleen
最近的研究表明，抑郁症和一系列身体疾病，包括心脏病，代谢综合征和2型糖尿病，都有炎症病因。在鱼和鱼油产品中发现的长链欧米茄-3脂肪酸（欧米茄-3s）二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）可以预防这些疾病，部分原因是它们可以降低炎症。本文综述了最近关于omega-3脂肪酸和女性心理健康的研究，特别关注围产期。这些研究包括调查鱼类消费的人口研究和测试EPA和DHA治疗抑郁症功效的研究。尽管研究结果喜忧参半，但大多数研究表明，EPA单独或与DHA和/或抗抑郁药物联合治疗抑郁症有效。DHA单独在心理健康中的作用尚不清楚，但它通常与EPA结合使用，似乎具有有益的效果。在中等剂量下，EPA和DHA对孕妇和产后妇女是安全的，并且患者耐受性良好。J Midwifery Womens Health 2010; 55：561 - 567（C）2010由美国护士助产士学院出版。
Recent research has shown that depression and a range of physical illnesses, including heart disease, metabolic syndrome, and type 2 diabetes, have an inflammatory etiology. The long-chain omega-3 fatty acids (omega-3s) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are found in fish and fish-oil products, may protect against these illnesses, in part because they lower inflammation. This article reviews the recent research on omega-3s and women's mental health, with a particular focus on the perinatal period. These studies include population studies examining fish consumption and studies testing the efficacy of EPA and DHA as treatments for depression. Although the findings are mixed, the majority of studies indicate that EPA has efficacy in treating depression either alone or in combination with DHA and/or antidepressant medications. The role of DHA alone in mental health is less clear, but it is generally combined with EPA and appears to have a beneficial effect. In moderate doses, EPA and DHA appear safe for pregnant and postpartum women, and they are well tolerated by patients. J Midwifery Womens Health 2010; 55: 561-567 (C) 2010 by the American College of Nurse-Midwives.