Effects of different ionic environments on the responses of single olfactory receptors in the lamprey
Effects of different ionic environments on the responses of single olfactory receptors in the lamprey
复制标题
不同离子环境对七鳃鳗单一嗅觉受体反应的影响
DOI：
10.1016/0300-9629(78)90065-8
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
Suzuki Noriyo
中科院分区：
文献类型：
--
作者：
Suzuki Noriyo
1.通过对细胞外记录的单一棘波频率直方图的分析，研究了不同离子环境对七鳃鳗嗅觉感受器反应的影响。2.2.受体对L-精氨酸刺激的反应幅度是外液中钙离子浓度的函数。在含有EGTA的无钙溶液中，受体反应被完全阻断。Na、K离子浓度变化不影响受体活性。3.La、Co离子对受体反应有抑制作用。La离子的影响比Co离子强得多。当溶液中有钙离子存在时，这些离子的抑制作用消失。4.结果提示，嗅觉感受器表面的钙离子对嗅觉感受器电位的产生起重要作用，可能是通过感受器膜的内向电流载体。
1. Effects of different ionic environments on the lamprey olfactory receptor response were studied by the analysis of frequency histograms of unitary spikes recorded extracellularly. 2. 2. The magnitude of the receptor response to l-arginine stimulus was a function of Ca ion concentration in the external solution. The receptor response was completely blocked in Ca-free solution containing EGTA. Na and K ion concentration changes did not influence the receptor activity. 3. 3. The receptor response was suppressed by La and Co ions. La ions had much stronger effects than Co ions. The suppression by these ions disappeared in the presence of Ca ions in the solution. 4. 4. The results suggest that Ca ions on the apical receptor surface play an important role for the generation of olfactory receptor potential, probably as inward current carriers through the apical receptor membrane.