Long-term effects of a priming dose and short-term infusion of amphetamine on striatal dopamine neurons in rats.
Long-term effects of a priming dose and short-term infusion of amphetamine on striatal dopamine neurons in rats.
复制标题
安非他明启动剂量和短期输注对大鼠纹状体多巴胺神经元的长期影响。
DOI：
10.1016/0014-2999(83)90546-0
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发表时间：
1983
影响因子：
5
通讯作者：
L. Steranka
中科院分区：
文献类型：
--
作者：
L. Steranka
（+）-硫酸安非他明启动剂量（15mg /kg i.p）与通过渗透微型泵释放的1.36 mg/ h给大鼠皮下输注16 h后，纹状体多巴胺（DA）、二羟基苯乙酸（DOPAC）、同型香草酸（HVA）和突触体对[3H]DA的摄取显著减少，持续至少12周。纹状体DA下降持续至药物治疗后24周。相比之下，纹状体DOPAC、HVA和突触体DA摄取水平在安非他明治疗24周后恢复到对照水平。
A priming dose (15 mg/kg i.p.) of (+)-amphetamine sulfate combined with a 16 h subcutaneous infusion of 1.36 mg of the drug per hour to rats via its release from osmotic minipumps produced marked decreases in striatal dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and the synaptosomal uptake of [3H]DA which lasted for at least 12 weeks. The decrease in striatal DA persisted through 24 weeks after drug treatment. In contrast, striatal levels of DOPAC, HVA and synaptosomal DA uptake recovered to control levels by 24 weeks after amphetamine treatment.