The disappearance rate of colloidal radio-gold from the circulation and its application to the estimation, of liver blood flow in normal and cirrhotic subjects.
The disappearance rate of colloidal radio-gold from the circulation and its application to the estimation, of liver blood flow in normal and cirrhotic subjects.
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胶体放射性金从循环中的消失率及其在正常和肝硬化受试者肝血流量估计中的应用。
DOI：
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发表时间：
1954
影响因子：
15.9
通讯作者：
A. Neumayr
中科院分区：
文献类型：
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作者：
H. Vetter;R. Falkner;A. Neumayr
Bradley、Ingelfinger、Bradley 和 Curry (1) 首次提出的估计人体肝脏血流量的溴磺素方法已被证明是各种工作者手中非常有用的工具。尽管对于肝外染料损失的问题以及单个肝静脉样本不能完全代表离开肝脏的所有血液的问题还没有完全一致，但通过研究正常和患病受试者的肝脏循环状态及其由运动、姿势、麻醉和各种药物引起的变化，已经收集了大量信息。然而，所采用的技术绝非简单，需要多名训练有素的人员团队合作。最近，一种完全不同的方法被应用于肝循环的研究。它基于这样的假设：肝脏和脾脏的吞噬细胞在单次通过中能够高效地从血流中去除胶体颗粒物质。如果这个假设成立，那么这种胶体从循环中消失的速度本质上就是肝脏血流量的一个参数。由于肝脏和脾脏相互串联，并且骨髓仅吸收极少量的这种胶体，Sheppard、Jordan 和 Hahn (2) 认为应该可以根据消失率常数计算肝脏血流量，即每单位时间灌注肝脏的血量分数。这个想法已经被付诸实践（3），他们使用放射性磷标记的磷酸铬作为颗粒物。然而，这种方法似乎又不像常规诊断程序所希望的那么简单。制备合适粒径的磷酸铬胶体是一个相当费力的过程，并且消失率的测定本身涉及抽取连续的血样，这对于患者来说导致大量的血液流失。因此，通过使用手头的胶体，并用缓解同位素对其进行标记，可以进一步简化人体肝脏血流量的估计，这将允许在外部确定消失率，而无需抽取血样。本文报告了使用胶体放射性金 (Au198) 作为颗粒物获得的一些结果，...
The bromsulphalein method of estimating liver blood flow in man first introduced by Bradley, Ingelfinger, Bradley, and Curry (1) has proved to be a very useful tool in the hands of various workers. Though there is not complete agreement as to the question of extrahepatic dye loss and the problem of a single hepatic vein sample not being entirely representative of all the blood leaving the liver, a considerable amount of information has been gathered by studying the state of liver circulation in normal and diseased subjects and its alterations produced by exercise, posture, anesthesia , and various drugs. However, the tech-nic employed is by no means a simple one and requires the team work of several highly trained people. Very recently, an entirely different method has been applied to the study of hepatic circulation. It is based on the assumption that the phagocytes of liver and spleen are highly efficient in removing colloid particulate matter from the blood stream in a single passage. If this assumption holds true, then the disappearance rate of this colloid from the circulation would essentially be a parameter of liver blood flow. Since the liver and spleen are in series with each other and since the bone marrow takes up only minimal amounts of this col-loid, it was felt by Sheppard, Jordan, and Hahn (2) that it should be possible to calculate liver blood flow from the disappearance rate constant as the fraction of blood volume perfusing the liver per unit time. This idea has been put into practice (3) who used chromic phosphate labeled with radiophosphorus as the particulate matter. However , this method again appears not to be as simple as one would want it to be for a routine diagnostic procedure. The preparation of a chromic phosphate colloid of suitable particle size is quite a laborious procedure, and the determination of the disappearance rate itself involves the withdrawal of serial blood samples which, to the patient, results in the loss of a considerable amount of blood. A further simplification of the estimation of liver blood flow in man would, therefore, be afforded by using a colloid readily at hand, and by labeling it with a Remitting isotope which would permit external determination of the disappearance rate without the need for withdrawing blood samples. The present paper reports some results obtained with colloidal radioactive gold (Au198) used as the particulate matter, the …