Inhibitory peptidergic neurons: functional difference between somatostatin and enkephalin in myenteric plexus.
Inhibitory peptidergic neurons: functional difference between somatostatin and enkephalin in myenteric plexus.
复制标题
抑制性肽能神经元：肌间神经丛中生长抑素和脑啡肽的功能差异。
DOI：
10.1152/ajpgi.1986.250.1.g60
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Youther,ML
中科院分区：
文献类型：
--
作者：
Yau,WM;Dorsett,JA;Youther,ML
本文报道了神经肽生长抑素和甲硫氨酸脑啡肽对豚鼠小肠肌间神经丛-纵肌条乙酰胆碱（ACh）释放的抑制作用的差异。甲硫氨酸脑啡肽（8.7 × 10 ~（-8）M）抑制P物质（3.7 × 10 ~（-8）M）或神经降压素（7.5 × 10 ~（-11）M）诱发的ACh释放，这种抑制作用可被纳洛酮（5 × 10 ~（-8）~ 5 × 10 ~（-5）M）逆转。神经紧张素诱导的ACh释放对生长抑素的抑制也很敏感。然而，当在6.1 X 10（-8）至6.1 X 10（-6）M的剂量范围内进行测试时，生长抑素在减少P物质诱发的ACh外排方面是无效的。这些观察结果提供了证据支持这样的观点，即肌间神经丛内的抑制性肽能神经元以高度特异性调节胆碱能神经元的活性，并且生长抑素和Met-1都是一种抑制性肽能神经元的受体。脑啡肽在肠道中具有独特的神经调节功能。
This study reports on a difference in the inhibitory action of the neuropeptides somatostatin and Met-enkephalin on acetylcholine (ACh) release from myenteric plexus-longitudinal muscle strips of guinea pig small intestine. Met-enkephalin (8.7 X 10(-8) M) inhibited ACh release evoked by either substance P (3.7 X 10(-8) M) or neurotensin (7.5 X 10(-11) M), and this inhibition could be reversed by naloxone (5 X 10(-8) to 5 X 10(-5) M). Neurotensin-induced ACh release was also sensitive to the inhibition by somatostatin. However, when tested in a dose range from 6.1 X 10(-8) to 6.1 X 10(-6) M, somatostatin was ineffective in reducing the efflux of ACh evoked by substance P. These observations provided evidence to support the view that inhibitory peptidergic neurons within the myenteric plexus modulate the activity of cholinergic neurons with a high degree of specificity and that both somatostatin and Met-enkephalin have distinct neuromodulatory functions in the gut.