Poor P50 suppression among schizophrenia patients and their first-degree biological relatives
Poor P50 suppression among schizophrenia patients and their first-degree biological relatives
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DOI：
10.1176/ajp.155.12.1691
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发表时间：
1998-12-01
影响因子：
17.7
通讯作者：
Braff, DL
中科院分区：
文献类型：
--
作者：
Clementz, BA;Geyer, MA;Braff, DL
目的：本研究的目的是重复精神分裂症患者家庭成员在配对点击听觉诱发反应范式中表现出较差的P50抑制的发现。方法：采用配对点击模式对44例精神分裂症患者、60例临床未受影响的一级亲属和45例正常人进行测试。在间隔500毫秒的背景白噪声为60分贝（83分贝）的情况下，对所有受试者播放60次点击音。使用标准方法和Ct记录点从数字滤波数据中选择第一和第二次点击的P50反应。结果：精神分裂症患者对点击1的P50反应小于其亲属和正常人；患者及其亲属对点击2的P50反应比正常受试者大，差异无统计学意义。精神分裂症患者的P50抑制比其家庭成员和正常人更严重；患者家属P50抑制较正常人更严重。结论：精神分裂症患者家属P50抑制较正常人严重。据作者所知，这是独立于科罗拉多大学相关小组的第一次证明精神分裂症患者的家庭成员P50抑制较差。这一结果在本质上是重要的，尤其是因为最近的一份报告表明P50抑制不良与胆碱能受体的α(7)烟碱亚基有遗传联系。
Objective: This study's goal was to replicate the finding that family members of schizophrenia patients show poor P50 suppression during a paired-click auditory evoked response paradigm. Method: The paired-click paradigm was used to test 44 schizophrenia patients, 60 of their clinically unaffected first-degree relatives, and 45 normal subjects. Two clicks (83 dB[A] over a 60-dB[A] white noise background) separated by 500 msec were presented 60 times to all subjects. P50 responses to the first and second clicks were selected from the digitally filtered data by using standard methods and the Ct recording site. Results: The schizophrenia patients had smaller P50 responses to click 1 than either their relatives or the normal subjects; the patients and their relatives, who did not significantly differ, had larger P50 responses to click 2 than the normal subjects. Schizophrenia patients had worse P50 suppression than either their family members or the normal subjects; the patients' family members had worse P50 suppression than the normal subjects. Conclusions: Family members of schizophrenia patients have worse P50 suppression than normal subjects. To the authors' knowledge, this is the first demonstration independent of the group associated with the University of Colorado that schizophrenia patients' family members have poor P50 suppression. This result is intrinsically important, perhaps especially because a recent report suggests genetic linkage of poor P50 suppression to the cholinergic receptor's alpha(7) nicotinic subunit.