Molecular epidemiology of live, attenuated varicella virus vaccine in children with leukemia and in normal adults.
Molecular epidemiology of live, attenuated varicella virus vaccine in children with leukemia and in normal adults.
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白血病儿童和正常成人活减毒水痘病毒疫苗的分子流行病学。
DOI：
10.1093/infdis/155.4.633
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Brown,AE
中科院分区：
文献类型：
--
作者：
Gelb,LD;Dohner,DE;Gershon,AA;Steinberg,SP;Waner,JL;Takahashi,M;Dennehy,PH;Brown,AE
水痘-带状疱疹病毒（VZV）DNA的限制性内切酶分析已被用于阐明接种水痘减毒活疫苗的个体中VZV感染的复杂流行病学。在接种疫苗后的前六周内出现的早期皮疹总是由疫苗病毒引起的。野生型VZV的真正突破性感染也发生在接种者中。在缓解期接种疫苗的白血病儿童中发现了5例带状疱疹。1例病例在接种后22个月出现在与接种相同的一般区域。分离的病毒是疫苗衍生的。第二例带状疱疹出现在与疫苗接种部位无关的皮区，发生在自然水痘后19个月。该病毒为野生型。因此，疫苗病毒可以建立潜伏期，并且可以稍后重新激活为带状疱疹。
Restriction endonuclease analysis of varicella-zoster virus (VZV) DNA has been used in unraveling the complex epidemiology of VZV infections in individuals immunized with a live, attenuated varicella virus vaccine. Early rashes appearing within the first six weeks after vaccination are invariably due to vaccine virus. True breakthrough infections with wild-type VZV also occur in vaccinees. Five cases of zoster have been seen in leukemic children vaccinated while in remission. One case appeared 22 months after vaccination in the same general area as the inoculation. The virus isolated was vaccine derived. A second case of zoster appeared in a dermatome unrelated to the sites of vaccination ∼19 months after apparently natural varicella. This virus was wild type. Vaccine virus can therefore establish latency and can later reactivate as herpes zoster.