A convenient large scale synthesis of 2,6‐dimethyl‐4‐(trimethylstannyl)pyridine
A convenient large scale synthesis of 2,6‐dimethyl‐4‐(trimethylstannyl)pyridine
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2,6-二甲基-4-(三甲基甲锡烷基)吡啶的便捷大规模合成
DOI：
10.1002/jhet.5570270661
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发表时间：
1990
影响因子：
2.4
通讯作者：
P. Pennock
中科院分区：
文献类型：
--
作者：
Baldev Singh;G. Lesher;P. Pennock
氯氧磷与2,6-二甲基吡啶n -氧化物盐酸盐(1)反应得到2-（氯甲基）-6-甲基吡啶(2)和4-氯-2,6-二甲基吡啶(3)的混合物。用三乙胺处理该混合物，将其转化为季盐4，季盐4通过水萃取分离，留下3，然后与三甲基锡基钠反应，得到2,6-二甲基-4-（三甲基锡基）吡啶(6)。
Reaction of phosphorus oxychloride with 2,6-dimethylpyridine N-oxide hydrochloride (1) gave a mixture of 2-(chloromethyl)-6-methylpyridine (2) and 4-chloro-2,6-dimethylpyridine (3). Treatment of this mixture with triethylamine converted 2 to the quaternary salt 4 which was separated by water extraction leaving 3 which was subsequently reacted with trimethylstannyl sodium to yield 2,6-dimethyl-4-(trimethylstannyl)pyridine (6).