Mechanism of elimination of phosphorylated histone H2AX from chromatin after repair of DNA double-strand breaks
Mechanism of elimination of phosphorylated histone H2AX from chromatin after repair of DNA double-strand breaks
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DOI：
10.1016/j.mrfmmm.2009.08.001
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发表时间：
2010-03-01
影响因子：
2.3
通讯作者：
Tomilin, N. V.
中科院分区：
文献类型：
--
作者：
Svetlova, M. P.;Solovjeva, L. V.;Tomilin, N. V.
染色质中的共价修饰在真核生物基因表达调控和DNA修复中起着重要作用。DNA中双链断裂（DSB）的形成之后是DSB周围的巨噬细胞染色质结构域中的替换组蛋白H2 AX中的C-末端丝氨酸的快速局部磷酸化和称为γ H2 AX灶的离散核灶的形成。这种染色质的表观遗传修饰代表了DNA损伤信号传导和修复的“组蛋白密码”，在过去十年中得到了广泛的研究。已知在DSB重新连接后，γ H2 AX病灶从细胞核中消除，但这种消除的分子机制仍有待建立。然而，γ H2 AX消除可以作为正常细胞和组织中DSB修复的有用标志物。本文综述了γ-H2 AX消除的动力学和可能的机制。(C)2009 Elsevier B. V.保留所有权利。
Covalent modifications of histories in chromatin play an important role in regulation of eukaryotic gene expression and DNA repair. Formation of double-strand breaks (DSBs) in DNA is followed by the rapid local phosphorylation of the C-terminal serine in the replacement histone H2AX in megabase chromatin domains around DSBs and formation of discrete nuclear foci called gamma H2AX foci. This epigenetic modification of chromatin represents the "histone code" for DNA damage signaling and repair and has been extensively studied during last decade. It is known that after DSB rejoining gamma H2AX foci are eliminated from the nucleus, but molecular mechanism of this elimination remains to be established. However, gamma H2AX elimination can serve as a useful marker of DSB repair in normal cells and tissues. In this paper the available data on kinetics and possible mechanisms of gamma H2AX elimination are reviewed. (C) 2009 Elsevier B.V. All rights reserved.