Photodynamic therapy (PDT) using topically applied δ-aminolevulinic acid (ALA) for the treatment of oral leukoplakia
Photodynamic therapy (PDT) using topically applied δ-aminolevulinic acid (ALA) for the treatment of oral leukoplakia
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DOI：
10.1034/j.1600-0714.2003.00068.x
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发表时间：
2003-07-01
影响因子：
3.3
通讯作者：
Ilewicz, L
中科院分区：
文献类型：
--
作者：
Sieron, A;Adamek, M;Ilewicz, L
Background: Photodynamic therapy (PDT) is a non-invasive method for topical and selective treatment of pre-malignant lesions of oral cavity. The aim of our study was to determine therapeutic response to PDT in patients with oral leukoplakia.Methods: Twelve patients participated in our study. Lesions affected a variety of intraoral sites. The most common location was buccal, gingival and mandibular mucosa. Patients were treated with topically applied 10% delta-aminolevulinic acid (ALA) and light from an argon-pumped dye laser. Irradiation was performed in several (6-8) sessions using light at 635 nm wavelength, delivering a total dose of 100 J/cm(2) per session.Results: A complete response was obtained in 10 out of 12 treated patients. One recurrence was observed during 6 months.Conclusion: Photodynamic therapy appears to be a feasible alternative to conventional therapy of pre-malignant lesions of oral cavity.
