Long-term taurine supplementation reduces mortality rate in streptozotocin-induced diabetic rats
Long-term taurine supplementation reduces mortality rate in streptozotocin-induced diabetic rats
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DOI：
10.1007/s00726-004-0108-2
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发表时间：
2004-10-01
期刊：
影响因子：
3.5
通讯作者：
Ghirlanda, G
中科院分区：
文献类型：
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作者：
Di Leo, MAS;Santini, SA;Ghirlanda, G
氧化应激与糖尿病的发病机制有关。在实验性糖尿病模型中补充牛磺酸和维生素E+硒有一定的益处。这项研究评估了牛磺酸和维生素E+硒补充剂是否能降低糖尿病死亡率等硬性终点。链脲佐菌素诱导的糖尿病大鼠给予标准饲料、牛磺酸(5%，w/w)或维生素E(500uI/kg)+硒(8 mg/kg)强化饲料喂养。牛磺酸显著降低死亡率(p<0.05)。
Oxidative stress is implicated in the pathogenesis of diabetes mellitus. Taurine and vitamin E + selenium supplementation has some benefits in experimental models of diabetes mellitus. This study evaluates whether taurine and vitamin E + selenium supplementations reduce a hard end-point such as mortality due to diabetes. Streptozotocin-induced diabetic rats were fed with standard diet or taurine (5%, w/w) or vitamin E (500 UI/Kg) + selenium (8 mg/Kg) enriched diets. Taurine significantly decreased mortality rate (p