Effect of some thiocarbamate compounds on aldehyde dehydrogenase and implications for the disulfiram ethanol reaction.
Effect of some thiocarbamate compounds on aldehyde dehydrogenase and implications for the disulfiram ethanol reaction.
复制标题
一些硫代氨基甲酸酯化合物对乙醛脱氢酶的影响及其对双硫仑乙醇反应的影响。
作者：
T. Kitson
研究了S二乙基二硫代氨基甲酸甲酯、S二乙基单硫代氨基甲酸酯和二(二乙基氨基甲酰基)二硫化物对绵羊肝脏胞浆乙醛脱氢酶的影响。第一种化合物的效果可以忽略不计。第二个是酶的酯酶活性的弱抑制剂和脱氢酶活性的弱抑制剂。然而，非常低浓度的第三种化合物可以有效地钝化乙醛脱氢酶，在这方面类似于二硫兰，尽管反应速度略慢。这些化合物可能参与的生理现象称为双硫胺乙醇反应进行了讨论。
The effects of S-methyl diethyldithiocarbamate, S-methyl diethylmonothiocarbamate and bis(diethylcarbamoyl) disulphide on sheep liver cytoplasmic aldehyde dehydrogenase were investigated in vitro. The first compound has negligible effect. The second one is a weak inhibitor of the esterase activity of the enzyme and a weaker inhibitor of the dehydrogenase activity. A very low concentration of the third compound, however, acts as a potent inactivator of aldehyde dehydrogenase, similar in this respect to disulfiram, although somewhat slower to react. The possible involvement of these compounds in the physiological phenomenon known as the disulfiram ethanol reaction is discussed.