Micronutrients in Oncological Intervention.
Micronutrients in Oncological Intervention.
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DOI：
10.3390/nu8030163
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发表时间：
2016-03-12
期刊：
影响因子：
5.9
通讯作者：
Adamietz IA
中科院分区：
文献类型：
--
作者：
Gröber U;Holzhauer P;Kisters K;Holick MF;Adamietz IA
营养补充剂被广泛用于癌症患者，他们认为它们是抗癌和抗毒性剂。根据恶性肿瘤的类型和性别，30%-90%的癌症患者在他们的饮食中补充抗氧化剂和免疫稳定微量营养素，如硒、维生素C和维生素D，通常治疗医生不知道。从肿瘤学的角度来看，有理由担心膳食补充剂会降低化疗和放疗的有效性。然而，最近的研究提供了越来越多的证据表明，当微量营养素，如硒，适当地加入到患者的药物中时，治疗的耐受性更好，患者的依从性增加，治疗中断率降低。根据个人的背景饮食、遗传学、肿瘤组织学和治疗方法量身定制的营养补充剂可能会对患者亚群产生益处。临床医生应该与患者就营养补充剂进行公开对话。补充建议需要个性化，来自可靠的来源，最好由医生传达。
Nutritional supplements are widely used among patients with cancer who perceive them to be anticancer and antitoxicity agents. Depending on the type of malignancy and the gender 30%–90% of the cancer patients supplement their diets with antioxidant and immuno-stabilizing micronutrients, such as selenium, vitamin C, and vitamin D, often without the knowledge of the treating physician. From the oncological viewpoint, there are justifiable concerns that dietary supplements decrease the effectiveness of chemotherapy and radiotherapy. Recent studies, however, have provided increasing evidence that treatment is tolerated better—with an increase in patient compliance and a lower rate of treatment discontinuations—when micronutrients, such as selenium, are added as appropriate to the patient’s medication. Nutritional supplementation tailored to an individual’s background diet, genetics, tumor histology, and treatments may yield benefits in subsets of patients. Clinicians should have an open dialogue with patients about nutritional supplements. Supplement advice needs to be individualized and come from a credible source, and it is best communicated by the physician.