Antibacterial Activities of Novel Diselenide-bridged bis(Porphyrin)s on Staphylococcus aureus Investigated by Microcalorimetry
Antibacterial Activities of Novel Diselenide-bridged bis(Porphyrin)s on Staphylococcus aureus Investigated by Microcalorimetry
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DOI：
10.1007/s12011-008-8156-1
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发表时间：
2008-08
影响因子：
3.9
通讯作者：
Xiang-jiao Xu;Z. Xue;Qi Xiao;A. Hou;Yi Liu
中科院分区：
文献类型：
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作者：
Xiang-jiao Xu;Z. Xue;Qi Xiao;A. Hou;Yi Liu
在37.00℃下，用微量热法研究了两种新型桥联双(卟啉)S(1和2)对金黄色葡萄球菌生长的影响，并与Na2SeO_3进行了比较。它们抑制生长代谢的能力存在差异。观察到金黄色。通过对功率-时间曲线的分析，确定了细菌生长速率常数(K)、抑制率(I)和世代时间(Tg)等关键参数。生长速率常数(K)OFS。在药物存在的情况下，金色(在对数阶段)随药物浓度的增加而规律地减少。二硒桥联双(卟啉)2的抗菌活性顺序为2 >； 1 >； Na_2SeO_3。
The actions of two novel diselenide-bridgedbis(porphyrin)s (1 and 2) onStaphylococcus aureusgrowth was investigated by microcalorimetry at 37.00°C, compared with that of Na2SeO3. Differences in their capacities to inhibit the growth metabolism ofS. aureuswere observed. By analyzing the power–time curves, crucial parameters such as the rate constant of bacterial growth (k), inhibitory rate (I), and generation time (tG) were determined. The growth rate constant (k) ofS. aureus(in the log phase) in the presence of the drugs decreased with increasing concentrations of the drugs regularly. The relationship ofkandcis nearly linear for diselenide-bridgedbis(porphyrin) 2. The sequence of the antibacterial activities of these selenium compounds tested was 2 > 1 > Na2SeO3.