Exploiting Sequence To Control the Hydrolysis Behavior of Biodegradable PLGA Copolymers
Exploiting Sequence To Control the Hydrolysis Behavior of Biodegradable PLGA Copolymers
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DOI：
10.1021/ja200895s
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发表时间：
2011-05-11
影响因子：
15
通讯作者：
Meyer, Tara Y.
中科院分区：
文献类型：
--
作者：
Li, Jian;Stayshich, Ryan M.;Meyer, Tara Y.
单体序列是一种潜在的强大但未得到充分利用的共聚物物性控制工具。序列被证明显著影响聚(乳酸-乙醇酸)(PLGA)的降解，PLGA是生物医学应用中使用最广泛的一类生物可降解聚合物的成员。在整个水解过程中，近乎线性的分子质量损失分布和均匀的热行为与具有相同共聚比的随机共聚物对照所表现出的行为有很大的不同。
Monomer sequence is a potentially powerful but underutilized tool for the control of copolymer properties. Sequence is demonstrated to dramatically affect the hydrolysis profile for the degradation of poly(lactic-co-glycolic acid) (PLGA), a member of the most widely used class of biodegradable polymers employed in biomedical applications. The nearly linear molecular weight loss profile and uniform thermal behavior throughout the course of the hydrolysis differ dramatically from the behavior that is exhibited by random copolymer controls with the same co-monomer ratio.