Cytotoxic polyprenylated benzoylphloroglucinol derivatives with an unusual adamantyl skeleton from Hypericum sampsonii (Guttiferae).
Cytotoxic polyprenylated benzoylphloroglucinol derivatives with an unusual adamantyl skeleton from Hypericum sampsonii (Guttiferae).
复制标题
DOI：
10.1002/chin.199947247
复制
发表时间：
1999-09
期刊：
影响因子：
5.2
通讯作者：
L. Hu;K. Sim
中科院分区：
文献类型：
--
作者：
L. Hu;K. Sim
[分子式：见正文] 已通过详细的光谱分析阐明了从中药植物金丝桃地上部分分离得到的sampsoniones I 和J 的结构。它们是复杂的金刚烷基衍生物，sampsonione I 是第一个具有独特的笼状四环[7.3.1.1.0]十四烷-2,12,14-三酮骨架的聚异戊二烯化苯甲酰间苯三酚衍生物。细胞毒性sampsonione I也通过sampsonione J的仿生转化获得。
[formula: see text] The structures of sampsoniones I and J, isolated from the aerial parts of the Chinese medicinal plant Hypericum sampsonii, have been elucidated by detailed spectral analysis. They are complex adamantyl derivatives, and sampsonione I is the first polyprenylated benzoylphloroglucinol derivative with the unique caged tetracyclo[7.3.1.1.0]tetradecane-2,12,14-trione skeleton. Cytotoxic sampsonione I has also been obtained by the biomimetic transformation of sampsonione J.