Prevalence of diabetes mellitus in Japanese patients infected chronically with hepatitis C virus
Prevalence of diabetes mellitus in Japanese patients infected chronically with hepatitis C virus
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DOI：
10.1007/s005350300063
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发表时间：
2003-04-01
影响因子：
6.3
通讯作者：
Kakumu, S
中科院分区：
文献类型：
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作者：
Arao, M;Murase, K;Kakumu, S
背景。为了研究日本人群中丙型肝炎病毒 (HCV) 感染与糖尿病 (DM) 之间的关系，对 866 名慢性病毒性疾病患者进行了一项回顾性研究。方法。本研究包括 707 名 HCV 感染者和 159 名乙型肝炎病毒 (HBV) 感染者。 HBV 和 HCV 相关肝硬化的患病率分别为 32% 和 33%。还进行了一项病例对照研究，以确定 459 名糖尿病患者的 HCV 感染血清流行率。结果。 HCV 感染者的 DM 患病率 (20.9%；P < 0.02) 高于 HBV 感染者 (11.9%)。在肝硬化患者中，HCV 患者中 30.8% 患有糖尿病，而 HBV 患者中这一比例为 11.8%（P < 0.01）。多变量分析显示，与 II 型糖尿病相关的主要自变量是男性（优势比，1.54；p = 0.020）和肝硬化（优势比，1.97；P = 0.0007）。据计算，HCV 感染的肝硬化患者发生 DM 的相对几率比 HBV 感染的患者高 3.2 倍。在糖尿病队列的病例对照研究中，10.5% 的患者感染 HCV，而 1.1% 的患者感染 HBV (P < 0.0001)。结果表明，与 HBV 感染相比，HCV 感染与 DM 密切相关。肝硬化是糖尿病的独立危险因素。结论。综上所述，研究结果表明，肝硬化似乎是比 HCV 感染更重要的葡萄糖耐受不良预测因子，这两个因素的结合会增加我们人群患糖尿病的风险。
Background. To examine the relationship between hepatitis C virus (HCV) infection and diabetes mellitus (DM) in Japanese populations, a retrospective study was done in 866 patients with chronic viral disease. Methods. The present study included 707 HCV-infected and 159 hepatitis B virus (HBV)-infected patients. The prevalences of HBV- and HCV-related cirrhosis were 32% and 33%, respectively. A case-control study was also conducted to determine the seroprevalence of HCV infection in a cohort of 459 diabetics. Results. The prevalence of DM was higher in HCV-infected patients (20.9%; P < 0.02) than in HBV-infected subjects (11.9%). In the cirrhotic patients, DM was observed in 30.8% of the subjects with HCV compared with 11.8% of those with HBV (P < 0.01). Multivariate analysis revealed that the major independent variables associated with type II DM were male sex (odds ratio, 1.54; p = 0.020) and cirrhosis (odds ratio, 1.97; P = 0.0007). The relative odds of the development of DM were calculated to be 3.2 times higher in HCV-infected cirrhotic patients than in HBV-infected ones. In the case-control study of the diabetic cohort, 10.5% of patients were infected with HCV compared with 1.1% with HBV (P < 0.0001). The results indicate that HCV infection is closely associated with DM, compared with HBV infection. Cirrhosis was an independent risk factor for DM. Conclusions. Taken together, the findings indicate that cirrhosis appears to be a more important predictor of glucose intolerance than HCV infection, and the combination of both factors increases the risk of DM in our populations.