Exercise training reduces inflammatory metabolic activity of visceral fat assessed by 18F-FDG PET/CT in obese women
Exercise training reduces inflammatory metabolic activity of visceral fat assessed by 18F-FDG PET/CT in obese women
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DOI：
10.1111/cen.14216
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发表时间：
2020-06-01
影响因子：
3.2
通讯作者：
Kim, Sungeun
中科院分区：
文献类型：
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作者：
Pahk, Kisoo;Kim, Eung Ju;Kim, Sungeun
目的肥胖通过诱导内脏脂肪组织（VAT）中巨噬细胞的炎症反应，提高VAT的炎症活性，从而增加心脏代谢疾病的风险。这项前瞻性研究旨在评估是否存在与全身炎症的炎症活动的增值税，以及是否运动可以改善炎症活动的增值税评估F-18-氟脱氧葡萄糖（FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）在肥胖women.Design和患者共23名肥胖妇女谁参加了运动计划。受试者在运动计划开始前（基线）和3个月运动计划完成后接受F-18-FDG PET/CT。为了评估VAT代谢活性，测量最大标准化摄取值（SUVmax）和平均标准化摄取值（SUVmean）。结果VAT基线SUVmax与脾脏、骨髓、hsCRP的SUVmax呈正相关，而VAT SUVmean无相关性。除肥胖外，运动还降低了VAT的SUVmax、脾脏的SUVmax、BM和hsCRP。然而，VAT SUVmean没有显著变化。结论在肥胖女性中，F18-FDG PET/CT测量的VAT的SUVmax与全身炎症相关，运动可降低VAT的SUVmax，消除其与全身炎症的相关性。
Objectives Obesity plays pivotal roles in the increased risk of cardiometabolic disease via induction of the inflammatory reaction from macrophages in visceral adipose tissue (VAT), which may elevate the inflammatory activity of VAT. This prospective study aimed to evaluate whether the inflammatory activity of VAT existed in association with systemic inflammation, and whether exercise could ameliorate the inflammatory activity of VAT assessed by F-18-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in obese women.Design and Patients A total of 23 obese women who participated in an exercise program were included. Subjects underwent F-18-FDG PET/CT before the start of the exercise program (baseline) and after the completion of the 3-month exercise program. For the assessment of VAT metabolic activity, the maximum standardized uptake value (SUVmax) and the mean standardized uptake value (SUVmean) were measured. The SUVmax of spleen, bone marrow (BM) and the high-sensitivity C-reactive protein (hsCRP) were used as a surrogate marker for systemic inflammation.Results Baseline SUVmax of VAT was positively correlated with the SUVmax of spleen, BM and hsCRP, whereas VAT SUVmean was not correlated. Exercise reduced SUVmax of VAT in addition to adiposity, the SUVmax of spleen, BM and hsCRP. However, VAT SUVmean was not significantly changed. Furthermore, the association of SUVmax of VAT, and the SUVmax of spleen, BM and hsCRP was no longer relevant after exercise.Conclusion In obese women, the SUVmax of VAT assessed by F-18-FDG PET/CT was associated with systemic inflammation and exercise reduced the SUVmax of VAT and abrogated its association with systemic inflammation.