Genetic polymorphisms, hormone levels, and hot flashes in midlife women
Genetic polymorphisms, hormone levels, and hot flashes in midlife women
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DOI：
10.1016/j.maturitas.2006.11.009
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发表时间：
2007-06-20
期刊：
影响因子：
4.9
通讯作者：
Flaws, Jodi A.
中科院分区：
文献类型：
--
作者：
Schilling, Chrissy;Gallicchio, Lisa;Flaws, Jodi A.
目的：潮热每年扰乱数百万妇女的生活。虽然潮热是一个公共健康问题，但人们对女性易患潮热的风险因素知之甚少。因此，本研究的目的是检查性类固醇激素水平和激素生物合成和降解酶的遗传多态性是否与潮热的风险相关。方法：采用横断面研究设计，从巴尔的摩及其周边县招募45-54岁的中年妇女（n = 639）。参与者完成了一份调查问卷，并捐献了血液样本用于类固醇激素分析和基因分型。基因多态性和激素水平之间的关联，以及基因多态性、激素水平和潮热之间的关联，使用统计模型进行了检验。结果：CYP1B1多态性与较低的脱氢表雄酮-硫酸氢表雄酮（DHEA-S）和孕酮水平相关，而CYP19（芳香化酶）多态性与较高的睾酮和DHEA-S水平相关。较低的黄体酮和性激素结合球蛋白水平、较低的游离雌二醇指数和较高的总雄激素与总雌激素之比与潮热有关。CYP1B1多态性和3 β HSD多态性都与潮热有关。结论：一些遗传多态性可能与中年妇女激素水平的改变有关。此外，选择的基因多态性和改变的激素水平可能与中年妇女潮热的风险有关。2006爱思唯尔爱尔兰有限公司版权所有。
Objective: Hot flashes disrupt the lives of millions of women each year. Although hot flashes are a public health concern, little is known about risk factors that predispose women to hot flashes. Thus, the objective of this study was to examine whether sex steroid hormone levels and genetic polymorphisms in hormone biosynthesis and degradation enzymes are associated with the risk of hot flashes.Methods: In a cross-sectional study design, midlife women aged 45-54 years (n = 639) were recruited from Baltimore and its surrounding counties. Participants completed a questionnaire and donated a blood sample for steroid hormone analysis and genotyping. The associations between genetic polymorphisms and hormone levels, as well as the associations between genetic polymorphisms, hormone levels, and hot flashes were examined using statistical models.Results: A polymorphism in CYP1B1 was associated with lower dehydroepiandrosterone-sulfate (DHEA-S) and progesterone levels, while a polymorphism in CYP19 (aromatase) was associated with higher testosterone and DHEA-S levels. Lower progesterone and sex hormone binding globulin levels, lower free estradiol index,and a higher ratio of total androgens to total estrogens were associated with the experiencing of hot flashes. A polymorphism in CYP1B1 and a polymorphism in 3 beta HSD were both associated with hot flashes.Conclusion: Some genetic polymorphisms may be associated with altered levels of hormones in midlife women. Further, selected genetic polymorphisms and altered hormone levels may be associated with the risk of hot flashes in midlife women. (c) 2006 Elsevier Ireland Ltd. All rights reserved.