Relaxations to SIN‐1, Nitric Oxide, and Sodium Nitroprusside in Canine Arteries and Veins
Relaxations to SIN‐1, Nitric Oxide, and Sodium Nitroprusside in Canine Arteries and Veins
复制标题
SIN-1、一氧化氮和硝普钠对犬动脉和静脉的松弛作用
DOI：
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发表时间：
1989
影响因子：
3
通讯作者：
P. Vanhoutte
中科院分区：
文献类型：
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作者：
V. Miller;P. Vanhoutte
本实验旨在比较吗西多明的活性代谢物SIN-1与一氧化氮（NO）和硝普钠的血管扩张特性。将犬股动、静脉环（带内皮和不带内皮）悬置于器官室中，测定等长收缩力。SIN-1和硝普钠放松血管环的存在和不存在的内皮细胞。然而，内皮素收缩的动脉和前列腺素F2α收缩的静脉中的内皮细胞减少了这些舒张作用。在动脉中，SIN-1、硝普钠和NO在舒张血管环方面是等效的，而血管环不受去甲肾上腺素或前列腺素F2α的收缩;当动脉受内皮素的收缩时，NO的作用不如其他两种血管舒张剂。在无内皮的静脉中，三种硝基血管扩张剂的效力相当;当用前列腺素F2α收缩时，静脉对扩张剂的作用比用内皮素或去甲肾上腺素收缩时更敏感。这些结果表明，SIN-1，硝普钠，NO是有效的动脉和静脉平滑肌的扩张剂，和扩张剂的效力可以改变内皮细胞和收缩激动剂在动脉和静脉的差异。
SUMMARY Experiments were designed to compare the vasodilator properties of SIN-1, the active metabolite of molsidomine, with nitric oxide (NO) and sodium nitroprusside. Rings of canine femoral arteries and veins with and without endothelium were suspended in organ chambers for the measurement of isometric force. SIN-1 and sodium nitroprusside relaxed rings of blood vessels in the presence and in the absence of the endothelium. However, these relaxations were reduced by the endothelial cells in arteries contracted with endothelin and in veins contracted with prostaglandin F2α. In the arteries, SIN-1, sodium nitroprusside, and NO were equipotent in relaxing rings without endothelium contracted with either norepinephrine or prostaglandin F2α; NO was less potent than the other two vasodilators when the arteries were contracted with endothelin. In the veins without endothelium, the potency of the three nitrovasodilators was comparable; the veins were more sensitive to the effects of the dilators when contracted with prostaglandin F2α than with either endothelin or norepinephrine. These results indicate that SIN-1, sodium nitroprusside, and NO are potent dilators of arterial and venous smooth muscle, and that the potency of the dilators can be altered by endothelial cells and the contractile agonist differentially in arteries and veins.