Three-dimensional myocardial contrast echocardiography: validation of in vivo risk and infarct volumes.
Three-dimensional myocardial contrast echocardiography: validation of in vivo risk and infarct volumes.
复制标题
三维心肌造影超声心动图：体内风险和梗塞体积的验证。
DOI：
10.1016/s0735-1097(97)00359-8
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发表时间：
1997
影响因子：
24
通讯作者：
Kaul,S
中科院分区：
文献类型：
--
作者：
Linka,AZ;Ates,G;Wei,K;Firoozan,S;Skyba,DM;Kaul,S
目标。本研究的目的是确定三维（3D）心肌对比超声心动图（MCE）是否能提供准确的体内风险和梗死体积评估。MCE已被证明可以在单片断层扫描中准确地确定危险区域和梗死面积。该技术通过三维超声心动图（3DE）测量风险和梗死体积的能力尚未确定。15只开胸犬接受不同时间冠状动脉闭塞后再灌注。各阶段均采用左心房注射AIP201进行MCE，其沉积微泡平均直径为10±4 μm，平均浓度为1.5·107·ml−1。使用自动旋转装置在180°弧度上获得图像，并以3D数据集的形式存储在计算机中。采用锝-99m放射自显影和组织染色分别在6 ~ 8片等厚度的左心室短轴片上测量死后危险面积和梗死面积。对这些平面对应的MCE图像进行离线重建。冠状动脉闭塞期间3D MCE造影未显示增强的心肌体积与死后危险体积呈密切线性关系（y = 1.2x - 3.0, r = 0.83, SEE = 5.1, n = 15）。再灌注后3D MCE造影未显示增强的心肌体积也与死后梗死体积密切相关（y = 1.1x - 3.9, r = 0.88, SEE = 4.8, n = 11）。注射aip201对全身血流动力学指标无明显影响。当与AIP201（沉积微泡）结合使用时，3D MCE可以准确地确定体内的风险和梗死体积。该方法可用于评估试图改变梗死/危险体积比的干预措施的效果。
Objectives. The aim of this study was to determine whether three-dimensional (3D) myocardial contrast echocardiography (MCE) could provide an accurate in vivo assessment of risk and infarct volumes.Background. MCE has been shown to accurately define risk area and infarct size in single tomographic slices. The ability of this technique to measure risk and infarct volumes by using three-dimensional echocardiography (3DE) has not been determined.Methods. Fifteen open chest dogs underwent variable durations of coronary artery occlusion followed by reperfusion. At each stage, MCE was performed by using left atrial injection of AIP201, a deposit microbubble with a mean diameter of 10 ± 4 μm and a mean concentration of 1.5·107·ml−1. Images were obtained over a 180° arc with use of an automated rotational device and were stored in computer as a 3D data set. Postmortem risk area and infarct size were measured in six to eight left ventricular short-axis slices of equal thickness using technetium-99m autoradiography and tissue staining, respectively. MCE images corresponding to these planes were reconstructed off-line.Results. A close linear relation was noted between the volume of myocardium not showing contrast enhancement on 3D MCE during coronary occlusion and postmortem risk volume (y = 1.2x − 3.0, r = 0.83, SEE = 5.1, n = 15). The volume of myocardium not showing contrast enhancement on 3D MCE after reperfusion also closely correlated with postmortem infarct volume (y = 1.1x − 3.9, r = 0.88, SEE = 4.8, n = 11). No changes in systemic hemodynamic variables were noted with injections of AIP201.Conclusions. When combined with AIP201, a deposit microbubble, 3D MCE can be used to accurately determine both risk and infarct volumes in vivo. This method could be used to assess the effects of interventions that attempt to alter the infarct/risk volume ratio.