Identification of TEM-135 β-Lactamase in Penicillinase-Producing Neisseria gonorrhoeae Strains in Japan

Identification of TEM-135 β-Lactamase in Penicillinase-Producing Neisseria gonorrhoeae Strains in Japan
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DOI:
10.1128/aac.00245-10
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发表时间:
2010-07-01
影响因子:
4.9
通讯作者:
Okamura, Noboru
Okamura, Noboru
中科院分区:
医学2区
文献类型:
--
作者:
Ohnishi, Makoto;Ono, Emi;Okamura, Noboru

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对2000 ~ 2008年分离的10株产青霉素酶淋球菌(PPNG)进行多位点序列分型、多抗原序列分型和质粒分型。序列分析显示,8株菌株含有TEM-1 β -内酰胺酶基因。然而,2004年和2008年分离的另外两株遗传上不同的PPNG菌株,在不同的质粒上都含有TEM-135 β -内酰胺酶,一个多伦多/里约热内卢型质粒和一个亚洲型R质粒,表明这些PPNG菌株的起源是独立的。
Ten penicillinase-producing Neisseria gonorrhoeae (PPNG) strains isolated from 2000 to 2008 were characterized by multilocus sequence typing, multiantigen sequence typing, and plasmid typing. Sequence analysis showed that 8 strains contained a TEM-1 beta-lactamase gene. However, two other genetically distinct PPNG strains, isolated in 2004 and 2008, each contained a TEM-135 beta-lactamase on different plasmids, a Toronto/Rio type R plasmid and an Asia type R plasmid, suggesting independent origins of these PPNG strains.