Freedom of movement and the stability of its unfolding in free exploration of mice
Freedom of movement and the stability of its unfolding in free exploration of mice
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DOI：
10.1073/pnas.0812513106
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发表时间：
2009-12-15
影响因子：
11.1
通讯作者：
Golani, Ilan
中科院分区：
文献类型：
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作者：
Fonio, Ehud;Benjamini, Yoav;Golani, Ilan
探索是人类和动物行为的一个核心组成部分，在啮齿动物中已经研究了近世纪。神经科学家用来描述全面探索的方法，在揭示探索过程的动力学方面是有限的，它的结构和意义的形态发生是隐藏的。通过使用先进的计算工具，摆脱饥饿，口渴，胁迫以及小笼子和短会话的限制，我们揭示了其在鼠标操作世界中的意义。探索由不断增加的幅度和自由度的反复往返组成，涉及鼠标移动的独立维度沿着数量的增加（宏观自由度）。这种可测量的梯度可以作为一个标准的参考尺度的发展动态的某些方面的小鼠的情绪认知状态和行为之间的接口和神经生理学和遗传过程介导的研究。
Exploration is a central component of human and animal behavior that has been studied in rodents for almost a century. The measures used by neuroscientists to characterize full-blown exploration are limited in exposing the dynamics of the exploratory process, leaving the morphogenesis of its structure and meaning hidden. By unfettering exploration from constraints imposed by hunger, thirst, coercion, and the confines of small cage and short session, using advanced computational tools, we reveal its meaning in the operational world of the mouse. Exploration consists of reiterated roundtrips of increasing amplitude and freedom, involving an increase in the number of independent dimensions along which the mouse moves (macro degrees of freedom). This measurable gradient can serve as a standard reference scale for the developmental dynamics of some aspects of the mouse's emotional-cognitive state and for the study of the interface between behavior and the neurophysiologic and genetic processes mediating it.