Elevated Circulating Levels of the Pro-Inflammatory Cytokine Macrophage Migration Inhibitory Factor in Individuals With Acute Spinal Cord Injury
Elevated Circulating Levels of the Pro-Inflammatory Cytokine Macrophage Migration Inhibitory Factor in Individuals With Acute Spinal Cord Injury
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DOI：
10.1016/j.apmr.2014.10.021
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发表时间：
2015-04-01
影响因子：
4.3
通讯作者：
Bloom, Ona
中科院分区：
文献类型：
--
作者：
Bank, Matthew;Stein, Adam;Bloom, Ona
目的：为了检验巨噬细胞移动抑制因子（MIF）在急性脊髓损伤（SCI）个体的循环中与未受伤个体相比升高的假设。设计：前瞻性、观察性试点研究。设置：学术医学中心。参与者：急性创伤性SCI成人（n=18）和未受伤参与者（n=18），在年龄和性别分布上可比较。干预措施：主要结果测量：主要结果测量是血浆MW水平。MIF和临床/人口统计学变量之间的潜在相关性进行了检查。次要结果是确定急性SCI参与者的其他免疫介质是否升高，以及它们的水平是否与MIF相关。
Objective: To test the hypothesis that macrophage migration inhibitory factor (MlF) is elevated in the circulation of individuals with acute spinal cord injury (SCI) compared with uninjured individuals.Design: Prospective, observational pilot study.Setting: Academic medical center.Participants: Adults with acute traumatic SCI (n=18) and uninjured participants (n=18), comparable in age and sex distribution.Interventions: Not applicable.Main Outcome Measures: The primary outcome measure was the plasma MW levels. Potential correlations were examined between MIF and clinical/demographic variables. The secondary outcome was to determine if other immune mediators were elevated in participants with acute SCI and if their levels correlated with the MIF.Results: MW was significantly elevated in subjects with acute SCI compared with control subjects at 0 to 3 (P