Associations of Factor VIII and von Willebrand Factor with Age, Race, Sex, and Risk Factors for Atherosclerosis
Associations of Factor VIII and von Willebrand Factor with Age, Race, Sex, and Risk Factors for Atherosclerosis
复制标题
因子 VIII 和血管性血友病因子与年龄、种族、性别和动脉粥样硬化危险因素的关联
作者：
Maureen G. Conlan;A. Folsom;A. Finch;C. Davis;P. Sorlie;G. Marcucci;K. Wu
几种凝血蛋白已被认为是动脉粥样硬化性疾病发展的可能危险因素，其中包括因子VIII和血管性血友病因子。作为社区动脉粥样硬化风险研究（ARIC）的一部分，一项旨在评估动脉粥样硬化疾病发展危险因素的前瞻性研究，进行了因子VIII和血管性血友病因子（vWF）的基线测量，以确定它们与动脉粥样硬化发展的关系。我们在此报告因子VIII和vWF与体质、生活方式和生化因素的关系。因子VIII和vWF之间存在很强的相关性（r = 0.73），因此与危险因素具有相似的相关性。这两个因素的平均水平在女性中高于男性，在黑人中高于白人，并且随着年龄的增长而增加。在单变量分析中，两者都与糖尿病、体重指数、腰臀比、血清胰岛素和血浆甘油三酯呈正相关。两者都与酒精摄入量、教育水平、体育活动（有一些例外）和高密度脂蛋白胆固醇呈负相关。未观察到因子VIII或vWF与血浆ldl -胆固醇或脂蛋白之间的相关性(a)。尽管因子VIII在两性中与吸烟呈负相关，但vWF与吸烟状况无关。这些关联在多变量分析中得到证实。观察到的最强关联是因子VIII和vWF与种族和糖尿病。在多变量分析中，黑人的因子VIII和vWF水平比白人高15到18个百分点，糖尿病患者的因子VIII和vWF水平比非糖尿病患者高11到18个百分点。在分析因子VIII和vWF在动脉粥样硬化性疾病发展中的可能作用时，必须考虑到这些关联。
Summary Several coagulation proteins have been implicated as possible risk factors for the development of atherosclerotic diseases, among which are factor VIII and von Willebrand factor. As part of the Atherosclerosis Risk in Communities (ARIC) Study, a prospective study designed to assess risk factors for the development of atherosclerotic diseases, baseline measurements of factor VIII and von Willebrand factor (vWF) were performed to determine their relationship to the development of atherosclerosis. We herein report the associations of factor VIII and vWF with constitutional, lifestyle, and biochemical factors. Factor VIII and vWF were strongly correlated with each other (r = 0.73), and, therefore, had similar associations with risk factors. Mean levels of both factors were higher in women than in men, in blacks than in whites, and increased with age. In univariate analysis, both were positively associated with diabetes, body mass index, waist-to-hip ratio, serum insulin, and plasma triglycerides. Both were negatively associated with alcohol intake, educational level, physical activity (with some exceptions), and HDL-cholesterol. No correlations were observed between factor VIII or vWF and plasma LDL-cholesterol or lipoprotein(a). Although factor VIII was negatively associated with smoking in both sexes, vWF was not associated with smoking status. Most of these associations were confirmed in multivariate analysis. The strongest associations observed were of factor VIII and vWF with race and diabetes. In multivariate analysis, blacks had factor VIII and vWF levels 15 to 18 percentage points higher than whites, and diabetics had factor VIII and vWF levels 11 to 18 percentage points higher than non-diabetics. These associations must be taken into account when analyzing the possible role of factor VIII and vWF in the development of atherosclerotic diseases.
DOI：
10.1001/jama.1987.03400090067035
发表时间：
1987-09
期刊：
JAMA
影响因子：
--
作者：
W. Kannel;P. Wolf;W. Castelli;R. D'Agostino
通讯作者：
W. Kannel;P. Wolf;W. Castelli;R. D'Agostino
糖尿病和动脉粥样硬化中纤溶和凝血因子 VIII、抗原和瑞斯托菌素辅因子的变化。
影响因子：
7.5
作者：
Bern,MM;Cassani,MP;Horton,J;Rand,L;Davis,G
通讯作者：
Davis,G