Stochastic Alternating Dynamics for Synchronous EAD-Like Beating Rhythms in Cultured Cardiac Myocytes

Stochastic Alternating Dynamics for Synchronous EAD-Like Beating Rhythms in Cultured Cardiac Myocytes
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培养心肌细胞中同步 EAD 样搏动节律的随机交替动力学

DOI:
10.1088/0256-307x/26/11/110501
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发表时间:
2009-11
影响因子:
3.5
通讯作者:
古华光
古华光
中科院分区:
物理与天体物理3区
文献类型:
--
作者:
刘志强;丁学利;张慧敏;杨明浩;张宁;任维;古华光

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溶解的心肌细胞可以偶联在一起,并在培养中产生同步搏动。我们观察到一个同步的早期后去极化(EAD)样的节奏在培养的心肌细胞和再现的实验观察在一个网络的数学模型,其动力学是接近一个霍普夫分岔。这种EAD样的节奏的机制是由于噪声引起的焦点和极限环之间的随机交替。这些结果提供了新的理解病理性心脏节律,如早期未成熟的搏动。
Dissolved cardiac myocytes can couple together and generate synchronous beatings in culture. We observed a synchronized early after-depolarization(EAD)-like rhythm in cultured cardiac myocytes and reproduced the experimental observation in a network mathematical model whose dynamics are close to a Hopf bifurcation. The mechanism for this EAD-like rhythm is attributed to noised-induced stochastic alternatings between the focus and the limit cycle. These results provide novel understandings for pathological heart rhythms like the early immature beatings.
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