INDUCTION OF PLASMA INTERLEUKIN-6 BY CIRCULATING ADRENALINE IN THE RAT
INDUCTION OF PLASMA INTERLEUKIN-6 BY CIRCULATING ADRENALINE IN THE RAT
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DOI：
10.1016/0306-4530(94)90005-1
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发表时间：
1994-01-01
影响因子：
3.7
通讯作者：
BERKENBOSCH, F
中科院分区：
文献类型：
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作者：
DERIJK, RH;BOELEN, A;BERKENBOSCH, F
肾上腺素是应激时由肾上腺髓质分泌的，被认为与炎症和免疫反应的控制有关。因此，我们研究了肾上腺素对血浆中主要促炎细胞因子之一白细胞介素-6 （IL-6）水平的影响。在这里，我们描述了在大鼠中，肾上腺素的SC管理诱导血浆IL-6浓度的剂量依赖性增加，在2小时后达到最大值。此外，静脉注射肾上腺素的剂量导致循环肾上腺素浓度与应激时观察到的相似，心率增强，血浆IL-6浓度增加。肾上腺素皮下注射和静脉输注后血浆IL-6升高可被肾上腺素能受体拮抗剂l-心得安阻断，而d-心得安则不能。基于这些数据，我们得出结论，在生理条件下，循环肾上腺素可能参与控制IL-6的产生，从而可能调节炎症反应。
Adrenaline, which is secreted from the adrenal medulla during stress, is considered to be involved in the control of inflammation and immune responses. Therefore, we studied the effects of adrenaline on the plasma levels of one of the major pro-inflammatory cytokines, interleukin-6 (IL-6). Here we describe that in rats, SC administration of adrenaline induces a dose-dependent increase in plasma IL-6 concentrations, reaching its maximum after 2 h. In addition, intravenous (IV) infusion of adrenaline in a dose resulting in circulating adrenaline concentrations similar to those observed during stress, enhanced heart rate and increased plasma IL-6 concentrations. The increase in plasma IL-6 in response to adrenaline given by subcutaneous (SC) route and by IV infusion could be blocked by the beta-adrenergic receptor antagonist l-propranolol but not by d-propranolol. Based on these data we conclude that under physiological conditions circulating adrenaline may be involved in the control of IL-6 production, and thereby may modulate inflammatory responses.