Yoga, aerobic and stretching exercise effects on neurocognition: Randomized controlled trial protocol.
Yoga, aerobic and stretching exercise effects on neurocognition: Randomized controlled trial protocol.
复制标题
瑜伽、有氧运动和伸展运动对神经认知的影响：随机对照试验方案。
DOI：
10.1016/j.cct.2023.107240
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发表时间：
2023
影响因子：
2.2
通讯作者：
Damoiseaux,JessicaS
中科院分区：
文献类型：
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作者：
Gothe,NehaP;Erlenbach,Emily;Garcia,Veronica;Malani,Revati;Voss,Stephanie;Camacho,PaulB;McAuley,Edward;Burd,Nicholas;Sutton,BradleyP;Damoiseaux,JessicaS
随着全球人口老龄化，认知能力下降和痴呆症的患病率预计将上升，造成重大的健康和经济负担。这项试验的目的是首次严格测试瑜伽训练作为一种身体活动干预的有效性，以减轻与年龄相关的认知衰退和损伤。我们正在对168名中老年人进行一项为期6个月的随机对照试验（RCT），以比较瑜伽与有氧运动在认知功能、大脑结构和功能、心肺健康、循环炎症和分子标记方面的功效。采用单盲、三臂随机对照试验，168名年龄在55-79岁之间的老年人将被分配到：哈达瑜伽组、有氧运动组或拉伸-健美积极对照组。参与者将参加为期6个月的小组锻炼，每周3次，每次1小时。综合神经认知测试、脑成像、心血管健康测试和抽血将在基线进行；6个月干预结束，12个月随访。我们感兴趣的主要结果是大脑区域，如海马体积和前额叶皮层，以及认知功能，如情景记忆、工作记忆和执行功能，这些通常受到衰老和阿尔茨海默病的影响。这项随机对照试验不仅可以测试瑜伽是否可以缓解与年龄相关的认知能力下降，而且还可以提供有氧运动的另一种选择，这对身体功能受损的老年人尤其有吸引力
As the global population ages, the prevalence of cognitive decline and dementia is expected to rise, creating a significant health and economic burden. The purpose of this trial is to rigorously test, for the first time, the efficacy of yoga training as a physical activity intervention to mitigate age-related cognitive decline and impairment. We are conducting a 6-month randomized controlled trial (RCT) of exercise among 168 middle aged and older adults to compare the efficacy of yoga vs. aerobic exercise on cognitive function, brain structure and function, cardiorespiratory fitness, and circulating inflammatory and molecular markers. Using a single-blind, three arm RCT, 168 older adults ages 55-79 will be assigned to either: a Hatha yoga group, an aerobic exercise group or a stretching-toning active control group. Participants will engage in hour long group exercise 3x/week for 6-months. A comprehensive neurocognitive test battery, brain imaging, cardiovascular fitness test, and a blood draw will take place at baseline; end of the 6-month intervention, and at 12-month follow-up. Our primary outcomes of interest are brain regions, such as hippocampal volume and prefrontal cortex, and cognitive functions, such as episodic memory, working memory and executive functions, that are typically affected by aging and Alzheimer's disease. Not only will this RCT test whether yoga is a means to mitigate age-related cognitive decline, but it may also offer an alternative to aerobic exercise, which could be particularly appealing to older adults with compromised physical functioning.ClinicalTrials.gov Identifier: NCT04323163