Unlocking the secrets of syndecans: Transgenic organisms as a potential key
Unlocking the secrets of syndecans: Transgenic organisms as a potential key
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DOI：
10.1023/a:1025352501148
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发表时间：
2002-05-01
影响因子：
3
通讯作者：
Bernfield, MR
中科院分区：
文献类型：
--
作者：
Bellin, R;Capila, I;Bernfield, MR
硫酸乙酰肝素蛋白聚糖已知可调节大量细胞外配体的活性，从而具有调节多种生物过程的潜力。我们实验室的长期研究重点是syndecans，这是主要的细胞表面硫酸肝素蛋白多糖家族之一。大多数关于syndecans的早期工作涉及生化研究，提供了关于其结构和假定的生物学作用的初步信息。近年来，转基因生物的发展使人们对syndecan的功能有了更全面的了解。对转基因syndecan-1和syndecan-3小鼠的研究表明，syndecan在调节摄食行为方面具有不可预见的作用。Syndecan-1敲除小鼠对wnt诱导的肿瘤发生和微生物发病的易感性降低。对果蝇的实验表明，syndecan首先在胚胎早期细胞化时表达，并可能在果蝇的早期发育阶段发挥作用。本文综述了以转基因小鼠和果蝇为模型系统所阐明的syndecans的不同功能。
Heparan sulfate proteoglycans are known to modulate the activity of a large number of extracellular ligands thereby having the potential to regulate a great diversity of biological processes. The long-term studies in our laboratory have focused on the syndecans, one of the major cell surface heparan sulfate proteoglycan families. Most early work on syndecans involved biochemical studies that provided initial information on their structure and putative biological roles. In recent years, the development of transgenic organisms has allowed a more complete understanding of syndecan function. Studies with transgenic syndecan-1 and syndecan-3 mice have demonstrated an unforeseen role for syndecans in the regulation of feeding behavior. Syndecan-1 knockout mice display a reduced susceptibility to both Wnt-induced tumorigenesis and microbial pathogenesis. Experiments with Drosophila show that syndecan is first expressed upon cellularization in the early embryo, and may play a role in the early developmental stages of the fly. This review focuses on these diverse functions of the syndecans that have been elucidated by the use of transgenic mice and Drosophila as model systems.