Mitogen activated protein kinases (MAPKs) as regulators of spermatogenesis and spermatozoa functions
Mitogen activated protein kinases (MAPKs) as regulators of spermatogenesis and spermatozoa functions
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DOI：
10.1016/j.mce.2007.11.011
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发表时间：
2008-01-30
影响因子：
4.1
通讯作者：
Naor, Zvi
中科院分区：
文献类型：
--
作者：
Almog, Tal;Naor, Zvi
精子发生是一个复杂的生物过程，受男性生殖系统的细胞因子和激素的调节，最终产生成熟的可活动精子。精子首先必须经历一系列称为获能的生化过程，然后是顶体反应和卵子受精。在此，我们综述了丝裂原活化蛋白激酶(MAPK)级联信号通路在精子发生和精子功能中的作用。(C)2007爱思唯尔爱尔兰有限公司。保留所有权利。
Spermatogenesis, culminating in the generation of mature motile spermatozoa, is a complex biological process that is regulated by cytokines and hormones of the male reproductive system. Spermatozoa must first undergo a series of biochemical processes termed capacitation, which is followed by acrosome reaction and egg fertilization. Here we review the role of mitogen-activated protein kinases (MAPK) cascades in spermatogenesis and spermatozoa functions. (c) 2007 Elsevier Ireland Ltd. All rights reserved.