Evidence for visceral hypersensitivity in high-anxiety rats
Evidence for visceral hypersensitivity in high-anxiety rats
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DOI：
10.1016/s0031-9384(99)00254-1
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发表时间：
2000-05-01
影响因子：
2.9
通讯作者：
Greenwood-Van Meerveld, B
中科院分区：
文献类型：
--
作者：
Gunter, WD;Shepard, JD;Greenwood-Van Meerveld, B
在肠易激综合征患者中，焦虑常常与内脏疼痛相关。根据这些信息，我们假设遗传上易焦虑的老鼠的内脏敏感性增加。为了检验这一假设，使用对结直肠扩张的内脏运动反射记录来估计高水平的内脏刺激水平；中度和低度焦虑大鼠。我们比较了无害性结肠直肠扩张对有和没有致敏结肠的大鼠的影响。在非致敏大鼠中，内脏运动反应因结直肠扩张而增加，其中在高度焦虑的 Wistar-Kyoto 品系中反应最大。结肠敏化显着增加了所有大鼠品系对结直肠扩张的内脏运动反应。总之，我们的数据表明，遗传决定的焦虑水平的表现似乎是胃肠道神经反应异常，导致高度焦虑动物的内脏过敏。 (C) 2000 Elsevier Science Inc. 保留所有权利。
In patients with irritable bowel syndrome, anxiety is often associated with visceral pain. Based on this information we hypothesized that rats genetically predisposed to anxiety have an increased visceral sensitivity. To test this hypothesis, visceromotor reflex recordings in response to colorectal distention were used to estimate the level of visceral stimulation in high; moderate-, and low-anxiety rats. We compared the effect of innocuous colorectal distension in rats with and without sensitized colons. In nonsensitized rats visceromotor responses were increased by colorectal distention with the greatest response in the high-anxiety Wistar-Kyoto strain. Sensitization of the colon significantly increased visceromotor responses to colorectal distention in all rat strains. In summary, our data suggested that a manifestation of a genetically determined anxiety level appeared to be abnormal neural responsiveness of the gastrointestinal tract leading to visceral hypersensitivity in high-anxiety animals. (C) 2000 Elsevier Science Inc. All rights reserved.