Molecular Mechanisms of Cholangiocarcinogenesis: Are Biliary Intraepithelial Neoplasia and Intraductal Papillary Neoplasms of the Bile Duct Precursors to Cholangiocarcinoma?
Molecular Mechanisms of Cholangiocarcinogenesis: Are Biliary Intraepithelial Neoplasia and Intraductal Papillary Neoplasms of the Bile Duct Precursors to Cholangiocarcinoma?
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DOI：
10.1016/j.soc.2008.12.001
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发表时间：
2009-04-01
影响因子：
1.9
通讯作者：
Roggin, Kevin King
中科院分区：
文献类型：
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作者：
Bickenbach, Kai;Galka, Eva;Roggin, Kevin King
胆管癌（CC）是一种罕见的恶性肿瘤，可发生于肝内或肝外胆道树的任何部位。虽然胆管癌发生的关键步骤尚不清楚，但假设CC可能通过两个关键的癌前病变发展：胆道上皮内瘤变（BilIN）和胆管内乳头状瘤变（IPNB）。这些病变可能分别类似于胰腺上皮内瘤变和导管内乳头状粘液瘤。本文概述了胆管癌通过BilIN和IPNB途径发生的分子基础。它强调了改变细胞增殖、肿瘤抑制和关键黏液、细胞粘附和基质蛋白损伤的基因突变。
Cholangiocarcinoma (CC) is a rare, malignant neoplasm that can develop from any site within the intrahepatic or extrahepatic biliary tree. Although the key steps of cholangiocarcinogenesis remain unknown, it has been hypothesized that CC may develop through two key premalignant precursor lesions: biliary intraepithelial neoplasia (BilIN) and intraductal papillary neoplasm of the bile duct (IPNB). These lesions probably are analogous to pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasm, respectively. This article outlines the molecular basis of cholangiocarcinogenesis through the BilIN and IPNB pathways. It highlights the genetic mutations that alter cellular proliferation, tumor suppression, and impairment of critical mucinous, cell-adhesion, and matrix proteins.