Case report - Successful treatment of intravascular malignant lymphomatosis with high-dose chemotherapy and autologous peripheral blood stem cell transplantation
Case report - Successful treatment of intravascular malignant lymphomatosis with high-dose chemotherapy and autologous peripheral blood stem cell transplantation
复制标题
DOI：
10.1038/sj.bmt.1703038
复制
发表时间：
2001-05-01
影响因子：
4.8
通讯作者：
Saito, Y
中科院分区：
文献类型：
--
作者：
Koizumi, M;Nishimura, M;Saito, Y
血管内恶性淋巴细胞增多症（IML）是一种罕见的全身性疾病，其特征是恶性B（很少T）淋巴细胞在小动脉、静脉和毛细血管腔内增殖。诊断需要皮肤，肝脏，肾脏，脑膜，或脑活检，但很少是在死前，在这份报告中，我们描述了一个病人谁死前诊断为IML的皮肤活检的结果。患者在化疗后行自体外周血造血干细胞移植（auto-PBSCT）治疗，术后第450天病情完全缓解，已存活30个月以上，是国内首例自体外周血造血干细胞移植治疗IML。
Intravascular malignant lymphocytosis (IML) is a rare systemic disease characterized by proliferation of malignant B (rarely T) lymphoid cells within the lumina of small arteries, veins, and capillaries. Diagnosis requires skin, liver, renal, meningeal, or brain biopsy, but is rarely made ante mortem, In this report, we describe a patient who had an ante mortem diagnosis of IML as a result of a skin biopsy. Autologous peripheral blood stem cell transplantation (auto-PBSCT) was successfully performed after chemotherapy, The patient has survived for more than 30 months since the onset of the disease and maintains complete remission on the 450th day post PBSCT, To our knowledge, this is the first case of IML treated by auto-PBSCT.