Altered transendothelial transport of hormones as a contributor to diabetes.
Altered transendothelial transport of hormones as a contributor to diabetes.
复制标题
激素的跨内皮转运改变了糖尿病的贡献。
DOI：
10.4093/dmj.2014.38.2.92
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发表时间：
2014-04
影响因子：
5.9
通讯作者：
Sweeney G
中科院分区：
文献类型：
--
作者：
Yoon N;Dang TQ;Chasiotis H;Kelly SP;Sweeney G
血管内皮是一种动态结构，负责生物材料在循环和间质液之间的分离和调节运动。激素和营养物质可以通过细胞外或细胞旁途径穿过内皮。跨细胞内皮转运在内皮功能的正常和异常生理中起着重要的作用。然而，对细胞旁通路的作用知之甚少。虽然糖尿病中内皮功能障碍的概念现在被广泛接受，但我们建议应该更详细地研究细胞旁运输的改变，并将其纳入该模型。在这篇综述中，我们提供内皮细胞旁通透性的概述，并讨论其在促进糖尿病和相关并发症发展中的潜在重要性。因此，我们也认为，如果更好地理解，内皮细胞旁通透性的改变可以被认为是糖尿病的潜在治疗靶点。
The vascular endothelium is a dynamic structure responsible for the separation and regulated movement of biological material between circulation and interstitial fluid. Hormones and nutrients can move across the endothelium either via a transcellular or paracellular route. Transcellular endothelial transport is well understood and broadly acknowledged to play an important role in the normal and abnormal physiology of endothelial function. However, less is known about the role of the paracellular route. Although the concept of endothelial dysfunction in diabetes is now widely accepted, we suggest that alterations in paracellular transport should be studied in greater detail and incorporated into this model. In this review we provide an overview of endothelial paracellular permeability and discuss its potential importance in contributing to the development of diabetes and associated complications. Accordingly, we also contend that if better understood, altered endothelial paracellular permeability could be considered as a potential therapeutic target for diabetes.