Current and Future Applications of Fluorescence Guidance in Orthopaedic Surgery.
Current and Future Applications of Fluorescence Guidance in Orthopaedic Surgery.
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DOI：
10.1007/s11307-022-01789-z
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发表时间：
2023-02
影响因子：
3.1
通讯作者：
中科院分区：
文献类型：
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荧光引导手术 (FGS) 是一个不断发展的领域，旨在识别与外科手术执行相关的重要解剖结构或生理现象。荧光标记通常通过施用荧光报告基因来进行，所述荧光报告基因可以是分子靶向、酶激活或非靶向血管探针。荧光引导极大地改变了许多外科领域的护理策略；然而，骨科手术的研究和采用却滞后。 FGS 显示了通过多种应用改善骨科患者护理的潜力，包括疾病诊断、基于灌注的组织愈合能力评估、感染/肿瘤根除和解剖结构识别。这篇综述重点介绍了荧光引导在骨科领域当前和未来的应用，并确定了翻译的主要挑战和潜在的解决方案。
Fluorescence-guided surgery (FGS) is an evolving field that seeks to identify important anatomic structures or physiologic phenomena with helpful relevance to the execution of surgical procedures. Fluorescence labeling occurs generally via the administration of fluorescent reporters that may be molecularly targeted, enzyme-activated, or untargeted, vascular probes. Fluorescence guidance has substantially changed care strategies in numerous surgical fields; however, investigation and adoption in orthopaedic surgery have lagged. FGS shows the potential for improving patient care in orthopaedics via several applications including disease diagnosis, perfusion-based tissue healing capacity assessment, infection/tumor eradication, and anatomic structure identification. This review highlights current and future applications of fluorescence guidance in orthopaedics and identifies key challenges to translation and potential solutions.