Perioperative stress response in the dog: Effect of pre-emptive administration of medetomidine
Perioperative stress response in the dog: Effect of pre-emptive administration of medetomidine
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DOI：
10.1111/j.1532-950x.2000.00085.x
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发表时间：
2000-01-01
影响因子：
1.8
通讯作者：
Vanio, O
中科院分区：
文献类型：
--
作者：
Benson, GJ;Grubb, TL;Vanio, O
研究设计-前瞻性随机研究动物-十二只健康成年雌性目的繁殖狗，重16.8 - 25 kg。方法-以每周间隔对十二只狗中的每一只随机给予两种治疗：（1）肌内注射生理盐水15分钟后，面罩诱导异氟醚麻醉（ISO），维持潮气末浓度1.8%持续60分钟;和（2）美托咪定，15 μ g/kg IM，随后在15分钟内通过面罩诱导的异氟醚麻醉（ISO&MED）并维持在1.0%的潮气末浓度60分钟。在完成这两种治疗后一周，所有的狗都被切除卵巢，每种治疗（SURG和SURG&MED）六只接受。在美托咪定或生理盐水给药前即刻采集中心静脉血样（10 mL）在ISO和ISO& MED中，在注射美托咪定或盐水之前立即获得样品，并在注射美托咪定或盐水之后立即获得样品。（基线）和30岁时（皮肤切开前），45（卵巢韧带切除后），75（皮肤闭合后），105（皮肤闭合后30分钟，犬恢复并胸骨卧位）、初始采样后135、195、375分钟和24小时。分析样本的肾上腺素、去甲肾上腺素、促肾上腺皮质激素（ACTH）、皮质醇、胰岛素和葡萄糖。数据进行了方差分析和显着差异，发现一个最小的显着差异testsapplied.Results-premedication与美托咪定预防或延迟卵巢子宫切除术诱导的应激反应在isofurane麻醉dogs. Conclusions卵巢子宫切除术诱导的应激反应，虽然显着，是短的持续时间。美托咪定安全有效地降低了手术引起的应激反应。临床相关性--手术引起的应激反应可以通过美托咪定的给药来阻止或预防。（C）版权所有2000年由美国兽医学院。
Objective-To determine the effect of medetomidine on the stress response induced by ovariohysterectomy in isoflurane-anesthetized dogs.Study Design-Prospective randomized study.Animals-Twelve healthy adult female purpose-bred dogs, weighing 16.8 to 25 kg.Methods-Two treatments were randomly administered to each of twelve dogs at weekly intervals: (1) Saline injected IM followed in 15 minutes by isoflurane anesthesia (ISO) induced by mask and maintained at an end-tidal concentration of 1.8% for 60 minutes; and (2) Medetomidine, 15 mu g/kg IM followed in 15 minutes by isoflurane anesthesia (ISO&MED) induced by mask and maintained at an end-tidal concentration of 1.0% for 60 minutes. One week after completion of these two treatments, all dogs were ovariohysterectomized, six receiving each treatment (SURG and SURG&MED). Central venous blood samples (10 mL) were obtained immediately before medetomidine or saline (baseline) and at 30, 75, and 195 minutes and 2 1 hours after administration of medetomidine or saline in ISO and ISO&MED. In SURG and SURG&MED, samples were obtained immediately prior to injection of medetomidine or saline (baseline) and at 30 (before skin incision), 45 (after severence of the ovarian ligament), 75 (after skin closure), 105 (30 minutes after skin closure, dog recovered and in sternal recumbency), 135, 195, 375 minutes, and 24 hours after the initial sample. Samples were analyzed for epinephrine, norepinephrine, adrenocorticotrophic hormone (ACTH), cortisol, insulin, and glucose. Data were analyzed by analysis of variance and where significant differences were found, a least significant difference test was applied.Results-Premedication with medetomidine prevented or delayed the stress response induced by ovariohysterectomy in isoflurane-anesthetized dogs.Conclusions-The stress response induced by ovariohysterectomy, although significant, is of short duration. Medetomidine safely and effectively reduced surgically-induced stress responses.Clinical Relevance-Surgically induced stress responses can be obtunded or prevented by administration of medetomidine. (C)Copyright 2000 by The American College of Veterinary Surgeons.