Thinking Across Generations: Unique Contributions of Maternal Early Life and Prenatal Stress to Infant Physiology
Thinking Across Generations: Unique Contributions of Maternal Early Life and Prenatal Stress to Infant Physiology
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DOI：
10.1016/j.jaac.2017.09.001
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发表时间：
2017-11-01
影响因子：
13.3
通讯作者：
Drury, Stacy S.
中科院分区：
文献类型：
--
作者：
Gray, Sarah A. O.;Jones, Christopher W.;Drury, Stacy S.
目的：呼吸性窦性心律失常（RSA）是一种副交感神经介导的自我调节生物标志物，与一生的心理和身体健康结果相关。母亲承受产前压力的代际影响已被证明，但缺乏母亲孕前压力（包括不良童年经历（ACE））对婴儿 RSA 的生物嵌入的证据。我们研究了母亲 ACE 和产前压力对婴儿 RSA 的独立影响，旨在扩大对心理和身体健康风险最早起源的理解。& para;& para;方法：母亲报告 ACE 和产前压力。在二元压力源（Still Face Paradigm）期间，记录了 167 名 4 个月大婴儿（49% 女性和 51% 男性）样本中的 RSA。 结果：观察到母亲 ACE 和产前压力对婴儿 RSA 的独立贡献。高母亲 ACE 与较低 RSA 相关，而产前压力与压力源后未能恢复相关。观察到性别差异，但未观察到种族差异。产前压力与男孩中较高的 RSA 相关，但与女孩中较低的 RSA 相关。& para;& para;结论：婴儿的 RSA 受到母亲一生中压力经历的影响，ACE 预测较低的设定点和产前压力会抑制从压力中恢复。对于产前压力（而非 ACE），不同性别的模式有所不同。研究结果强调，对孕妇或考虑怀孕的女性进行减压干预可能会降低几代人的身心健康风险。
Objective: Respiratory sinus arrhythmia (RSA) is a parasympathetic-mediated biomarker of self-regulation linked to lifespan mental and physical health outcomes. Intergenerational impacts of mothers' exposure to prenatal stress have been demonstrated, but evidence for bio logical embedding of maternal preconception stress, including adverse childhood experiences (ACEs), on infant RSA is lacking. We examine the independent effects of maternal ACEs and prenatal stress on infant RSA, seeking to broaden the understanding of the earliest origins of mental and physical health risk.& para;& para;Method: Mothers reported on ACEs and prenatal stress. RSA was recorded in a sample of 167 4-month-old infants (49% female and 51% male) during a dyadic stressor, the Still Face Paradigm.& para;& para;Results: Independent contributions of maternal ACEs and prenatal stress to infant RSA were observed. High maternal ACEs were associated with lower RSA, whereas prenatal stress was associated with failure to recover following the stressor. Sex but not race differences were observed. Prenatal stress was associated with higher RSA among boys but lower RSA among girls.& para;& para;Conclusion: Infants' RSA is affected by mothers' life course experiences of stress, with ACEs predicting a lower set point and prenatal stress dampening recovery from stress. For prenatal stress but not ACEs, patterns vary across sex. Findings underscore that stress-reducing interventions for pregnant women or those considering pregnancy may lead to decreased physical and mental health risk across generations.