Modification of constrained peptides by ring-closing metathesis reaction
Modification of constrained peptides by ring-closing metathesis reaction
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DOI：
10.1016/s0960-894x(01)00227-x
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发表时间：
2001-06-04
影响因子：
2.7
通讯作者：
Durani, S
中科院分区：
文献类型：
--
作者：
Kotha, S;Sreenivasachary, N;Durani, S
用α，α-二烯丙基甘氨酰肽的闭环复分解（RCM）显示出提供α，α-环戊烯基甘氨酰肽，其为适合于肽模拟物和组合化学应用的翻译后型肽修饰形式的构象受限制的类似物。(C)2001爱思唯尔科技有限公司版权所有。
Ring-closing metathesis (RCM) with alpha,alpha -diallylglycyl peptides is shown to furnish alpha,alpha -cyclopentenylglycyl peptides as conformationally restrained analogues in the form of post-translational type peptide modification suitable for both peptidomimetic and combinatorial chemistry applications. (C) 2001 Elsevier Science Ltd. All rights reserved.