The ECO•SENS Project:: a prospective, multinational, multicentre epidemiological survey of the prevalence and antimicrobial susceptibility of urinary tract pathogens -: interim report
The ECO•SENS Project:: a prospective, multinational, multicentre epidemiological survey of the prevalence and antimicrobial susceptibility of urinary tract pathogens -: interim report
复制标题
DOI：
10.1093/jac/46.suppl_1.15
复制
发表时间：
2000-09-01
影响因子：
5.2
通讯作者：
Kahlmeter, G
中科院分区：
文献类型：
--
作者：
Kahlmeter, G
生态。SENS项目是第一个调查妇女社区获得性、无并发症尿路感染（uti）病原菌患病率和易感性的国际调查。在17个国家的240个中心，要求出现无并发症尿路感染症状的女性患者提供尿液样本，以检测白细胞和细菌的存在。鉴定细菌，并测定其对12种常用抗生素的敏感性。调查的目的是收集5000份尿液样本，以获得约3500株明确的尿路病原体。这份中期报告包括1960份尿液样本的结果，其中75%含有尿路病原体。在所有17个国家分离的尿路病原体中，大肠杆菌占大多数（80%）。大肠杆菌菌株的耐药率为：氨苄西林和磺胺甲恶唑，占30%；单独使用甲氧苄啶或与磺胺甲恶唑联合使用，15%；钠地酸，6%；ciprofoxacin, 3%;阿莫西林-克拉维酸、美西林、头孢地诺酯、呋喃妥因和磷霉素，小于或等于2%。氨苄西林、磺胺类药物和甲氧苄啶单独使用或与磺胺甲恶唑联合使用需要重新考虑。在一些国家，社区获得性大肠杆菌中喹诺酮类药物耐药性似乎迅速增加，这引起了人们的关注。
The ECO.SENS Project is the first international survey to investigate the prevalence and susceptibility of pathogens causing community-acquired, uncomplicated urinary tract infections (UTIs) in women. At 240 centres in 17 countries, female patients presenting with symptoms of uncomplicated UTIs were asked to provide a urine sample for testing for the presence of leucocytes and bacteria. The bacteria were identified and their susceptibility to 12 antibiotics commonly used in the treatment of UTIs was determined. The objective of the survey was to collect 5000 urine samples to obtain approximately 3500 isolates of defined uropathogens. This interim report includes the results from 1960 urine samples, 75% of which contained a uropathogen. Escherichia coli accounted for the majority (80%) of uropathogens isolated in all 17 countries. The rates of resistance among E. coli strains were: ampicillin and sulphamethoxazole, 30%; trimethoprim alone or with sulphamethoxazole, 15%; nalidixic acid, 6%; ciprofoxacin, 3%; amoxycillin-clavulanic acid, mecillinam, cefadroxil, nitrofurantoin and fosfomycin, less than or equal to 2%. The use of ampicillin, sulphonamides and trimethoprim alone or with sulphamethoxazole needs to be reconsidered. The seemingly rapid increase in quinolone resistance among community-acquired E. coli in some of the countries gives cause for concern.