Effectiveness of periodontal therapy in patients with drug-induced gingival overgrowth. Long-term results
Effectiveness of periodontal therapy in patients with drug-induced gingival overgrowth. Long-term results
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DOI：
10.1902/jop.1999.70.9.967
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发表时间：
1999-09-01
影响因子：
4.3
通讯作者：
Baylas, H
中科院分区：
文献类型：
--
作者：
Ilgenli, T;Atilla, G;Baylas, H
背景：药物性牙龈增生（DGO）是环孢菌素A（CsA）或硝苯地平（Ni）的公认副作用之一。牙周手术治疗后，DGO复发的发生率尚不清楚。本研究的目的是评估接受CsA或Ni治疗并表现出严重长期DGO的患者的牙周手术治疗结果。此外，各种变量之间的关系和复发的严重DGO后牙周surgics.Methods：共38例患者，22例CsA诱导DGO和16例镍诱导DGO，包括在这项研究中。在基线时，患者接受初步牙周治疗，然后对每位患者的上前段或下前段进行手术治疗。牙周手术治疗包括皮瓣技术与90度牙龈切除术切口。手术后，患者接受维持治疗回忆计划，并接受18个月的监测。前3个月每月随访1次，后15个月每3个月随访1次，每次随访时记录治疗节段的斑块指数（PI）、乳头出血指数（PBI）和DGO评分。出席召回任命也注意到为每个patient.Results：复发严重DGO观察13的38例（34%）18个月后牙周手术。多元回归分析表明，年龄，牙龈炎症，并出席召回任命的复发严重DGO.Conclusions的显着决定因素：本研究表明，定期再激励和专业护理在频繁的召回任命牙周手术后接受CsA或镍的患者是非常重要的。通过维护牙周健康，可以提高这些患者的生活质量。
Background: Drug-induced gingival overgrowth (DGO) is one of the well-recognized side effects of cyclosporin A (CsA) or nifedipine (Ni). After surgical periodontal therapy, the incidence of DGO recurrence is not known. The aim of this study was to evaluate the results of surgical periodontal therapy in patients receiving CsA or Ni and who exhibit severe long-term DGO. In addition, the relationship between various variables and the recurrence of severe DGO after periodontal surgery was investigated.Methods: A total of 38 patients, 22 with CsA-induced DGO and 16 with Ni-induced DGO, were included in this study. At baseline, patients received initial periodontal therapy, after which either the upper or lower anterior segment in each patient was surgically treated. Surgical periodontal therapy consisted of the flap technique with a 90 degrees gingivectomy incision. Following surgery, patients were placed on a maintenance therapy recall program and were monitored for 18 months. Patients were seen once a month for the first 3 months and once every 3 months for the following 15 months, Plaque index (PI), papilla bleeding index (PBI) and DGO scores in the treated segments were recorded at each recall appointment. Attendance at recall appointments was also noted for each patient.Results: Recurrence of severe DGO was observed in 13 of the 38 patients (34%) 18 months following periodontal surgery. Multiple regression analysis indicated that age, gingival inflammation, and attendance at recall appointments were significant determinants of the recurrence of severe DGO.Conclusions: This study suggests that regular re-motivation and professional care at frequent recall appointments after periodontal surgery are of great importance in patients receiving CsA or Ni. By maintaining periodontal health, the life quality of these patients may be raised.