I-BAR domain proteins: linking actin and plasma membrane dynamics
I-BAR domain proteins: linking actin and plasma membrane dynamics
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DOI：
10.1016/j.ceb.2010.10.005
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发表时间：
2011-02-01
影响因子：
7.5
通讯作者：
Lappalainen, Pekka
中科院分区：
文献类型：
--
作者：
Zhao, Hongxia;Pykalainen, Anette;Lappalainen, Pekka
动态质膜重排发生在许多细胞过程中，包括内吞作用、形态发生和迁移。肌动蛋白聚合与直接使膜变形的蛋白质（如BAR超家族蛋白）在内吞过程中对膜内陷的产生至关重要。重要的是，最近的研究表明，直接的膜变形也有助于形成质膜突起，如丝状足和板足。逆BAR （I-BAR）结构域蛋白以高亲和力结合富磷酸肌醇膜，产生负膜曲率，诱导质膜突出。I-BAR结构域蛋白，如IRSp53、MIM、ABBA和IRTKS，也含有许多蛋白质-蛋白质相互作用模块，将它们与肌动蛋白动力学联系起来。因此，在细胞形态发生和迁移过程中，I-BAR结构域蛋白可能直接将膜变形与肌动蛋白聚合联系起来。
Dynamic plasma membrane rearrangements occur during many cellular processes including endocytosis, morphogenesis, and migration. Actin polymerization together with proteins that directly deform membranes, such as the BAR superfamily proteins, is essential for generation of membrane invaginations during endocytosis. Importantly, recent studies revealed that direct membrane deformation contributes also to the formation of plasma membrane protrusions such as filopodia and lamellipodia. Inverse BAR (I-BAR) domain proteins bind phosphoinositide-rich membrane with high affinity and generate negative membrane curvature to induce plasma membrane protrusions. I-BAR domain proteins, such as IRSp53, MIM, ABBA, and IRTKS also harbor many protein-protein interaction modules that link them to actin dynamics. Thus, I-BAR domain proteins may connect direct membrane deformation to actin polymerization in cell morphogenesis and migration.