Congenital heart defects and fetal alcohol spectrum disorders.
Congenital heart defects and fetal alcohol spectrum disorders.
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DOI：
10.1111/j.1747-0803.2007.00105.x
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发表时间：
2007-07-01
影响因子：
0.3
通讯作者：
Klug, Marilyn G
中科院分区：
文献类型：
--
作者：
Burd, Larry;Deal, Eric;Klug, Marilyn G
目的：回顾先天性心脏病（CHD）和胎儿酒精谱系障碍（FASD）的患病率。设计：我们对Medline和Pubmed数据库进行了检索，以确定报告相关性的论文。然后，我们搜索的参考文献列表的文件和参考书的额外sources.Results：我们发现29个研究符合我们的纳入标准。在12项FASD受试者病例系列研究中，CHD（房[ASD]和室[VSD]间隔缺损、其他缺损或未指明的CHD）病例比例范围为33%至100%。在14项回顾性研究中，间隔缺损的发生率为21%，其他结构性缺损为6%，未指明的缺损为12%。对于2项病例对照研究，CHD的几率范围为1.0（胎儿酒精效应受试者）至18.0（胎儿酒精综合征受试者）。在1项CHD前瞻性研究中，儿童CHD和FASD的OR为1.0。关键结论：儿科心脏病专家可能经常接触FASD儿童，并增加对产前酒精暴露作为CHD潜在病因的关注。
OBJECTIVE: Review of the prevalence of congenital heart defects (CHD) and fetal alcohol spectrum disorder (FASD).DESIGN: We conducted a search of the Medline and Pubmed databases to identify papers reporting the association. We then searched the reference lists of the papers and reference books for additional sources.RESULTS: We found 29 studies that met our inclusion criteria. In the 12 case series studies of subjects with FASD, the proportion of cases with a CHD (atrial [ASD] and ventricular [VSD] septal defects, other defects, or unspecified CHD) ranged from 33% to 100%. From the 14 retrospective studies, the rate of septal defects was 21%, other structural defects 6% and unspecified defects was 12%. For the 2 case-control studies, the odds of CHD ranged from 1.0 (subjects with fetal alcohol effect) to 18.0 (subjects with fetal alcohol syndrome). In the 1 prospective study of CHD the OR for a child to have CHD and FASD was 1.0.KEY CONCLUSION: Pediatric cardiologists may have frequent contact with children with FASD and increased levels of attention to prenatal alcohol exposure as a potential etiology of CHD is indicated.