Sputum Trace Metals Are Biomarkers of Inflammatory and Suppurative Lung Disease
Sputum Trace Metals Are Biomarkers of Inflammatory and Suppurative Lung Disease
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DOI：
10.1378/chest.09-1047
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发表时间：
2010-03-01
期刊：
影响因子：
9.6
通讯作者：
Boyd, A. Christopher
中科院分区：
文献类型：
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作者：
Gray, Robert D.;Duncan, Andrew;Boyd, A. Christopher
背景：诱导痰细胞学和蛋白质生物标记物可用于评估呼吸道炎症。在炎症性肺部疾病中，痰中铁的增加被描述为。我们假设其他痰金属也可能受到呼吸道炎症的影响，并研究了它们作为生物标志物的潜在价值。方法：取自20名健康对照组和炎症性肺部疾病患者的痰(囊性纤维化23例，支气管扩张16例，哮喘17例，慢性阻塞性肺疾病23例)，测定铁、锌、锰和铜的含量。结果：慢性支气管炎患者和非慢性支气管扩张症患者痰锌、铁明显高于正常对照组(P
Background: Induced sputum cytology and protein biomarkers can be used to assess airways inflammation. Increases in sputum iron have been described in inflammatory lung disease. We hypothesized that other sputum metals may be affected by airways inflammation and investigated their potential value as biomarkers.Methods: Sputum was obtained from 20 healthy control subjects and from patients with inflammatory pulmonary diseases (23 with cystic fibrosis [CF], 16 with bronchiectasis, 17 with asthma, and 23 with COPD), and iron, zinc, manganese, and copper were measured. Fourteen patients with CF were also studied through an exacerbation cycle.Results: Sputum zinc and iron were elevated in CF and non-CF bronchiectasis vs controls (P