Green synthesis of nitriles using non-noble metal oxides-based nanocatalysts
Green synthesis of nitriles using non-noble metal oxides-based nanocatalysts
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DOI：
10.1038/ncomms5123
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发表时间：
2014-07-01
影响因子：
16.6
通讯作者：
Beller, Matthias
中科院分区：
文献类型：
--
作者：
Jagadeesh, Rajenahally V.;Junge, Henrik;Beller, Matthias
(杂环)芳香族和脂肪族腈是有机合成的主要构件，在许多医学和生物上重要的化合物中都有广泛的用途。一般来说，这些腈是通过使用有毒氰化物的传统氰化过程合成的。在绿色化学方面，开发更可持续和成本效益更高的高级氰化物合成工艺是非常必要的。在这里，我们报道了在氨水和分子氧的作用下，从容易获得的醇中合成各种结构多样的芳基、杂环、烯丙基和脂肪族腈的方法。这种合成成功的关键是使用氮掺杂的石墨烯层状非贵金属氧化物作为稳定和持久的纳米催化剂。作为一个例子，介绍了一种工业上重要的大宗化学品己二腈的可再生合成。
(Hetero) aromatic and aliphatic nitriles constitute major building blocks for organic synthesis and represent a versatile motif found in numerous medicinally and biologically important compounds. In general, these nitriles are synthesized by traditional cyanation procedures using toxic cyanides. With respect to green chemistry, the development of more sustainable and cost-efficient processes for the synthesis of advanced nitriles is highly desired. Here we report an environmentally benign synthesis of all kinds of structurally diverse aryl, hetero-cyclic, allylic and aliphatic nitriles from easily available alcohols applying aqueous ammonia and molecular oxygen. Key to success for this synthesis is the use of nitrogen-doped graphene-layered non-noble metal oxides as stable and durable nanocatalysts. As an example a renewable synthesis of adiponitrile, an industrially important bulk chemical is presented.