Boost photothermal theranostics via self‐assembly‐induced crystallization (SAIC)
Boost photothermal theranostics via self‐assembly‐induced crystallization (SAIC)
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DOI：
10.1002/agt2.170
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发表时间：
2022-01
期刊：
影响因子：
18.8
通讯作者：
Xueluer Mu;Fapu Wu;Ying Tang;Rui Wang;Yajie Li;Kaixuan Li;Chun-Ling Li;Yingxi Lu;
中科院分区：
文献类型：
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作者：
Xueluer Mu;Fapu Wu;Ying Tang;Rui Wang;Yajie Li;Kaixuan Li;Chun-Ling Li;Yingxi Lu;
由于光热治疗诊断技术具有时空选择性的内在优势，已成为癌症精准医疗的前沿。开发具有近红外（NIR）吸收、高光热转换效率、稳健的光热稳定性和在肿瘤中良好积累的光热转换剂（PTA）特别有价值。在此，我们提出了一个新的概念，自组装诱导结晶（SAIC），它可以作为一种机制，显着提高PTA在近红外区的光热行为。作为概念验证，设计了三个具有内部自由度（几何形状和分子内相互作用）的七甲川花青分子，以微调其结晶度。值得注意的是，具有刚性和平面骨架的Cy 7-TCF-恩比分子自组装成结晶状态，以最大化其堆积密度并改善电荷转移，这两者都有助于非辐射衰减以作为热量耗散能量。高堆积密度还提供了用于控制分子间相互作用的理想支架，以表现出更好的光热稳定性，并赋予用于被动肿瘤靶向的各向异性三维结构。这种“SAIC”策略可能提供了一种概念新颖、实际简单但有效的方法来揭示结构与性质关系，可以为PTA的合理设计提供一些一般规则，并为下一代光热治疗诊断学的超分子药物铺平道路。
Owing to the intrinsic advantages of spatiotemporal selectivity, photothermal theranostics have become the advancing edge of precision medicine for cancer. Developing photothermal transduction agents (PTAs) with near‐infrared (NIR) absorption, high photothermal conversion efficiency, robust photothermal stability, and good accumulation in tumors, is particularly valuable. Herein, we report a new concept, self‐assembly‐induced crystallization (SAIC), which can serve as a mechanism that dramatically boosts photothermal behaviors of PTA in NIR region. As a proof of concept, three heptamethine cyanine molecules with internal degrees of freedom (geometry and intramolecular interaction) are designed to fine‐tune their crystallinity. Notably, Cy7‐TCF‐EMBI molecules with rigid and planar skeletons self‐assemble into a crystalline state to maximize their packing density and improve the charge transfer, both of which contribute to nonradiative decay for energy dissipation as heat. The high packing density also renders an ideal scaffold for controlling intermolecular interactions to exhibit better photothermal stability, and endows an anisotropic three‐dimensional architecture for passive tumor targeting. This “SAIC” strategy may offer a conceptually novel, practically simple but effective approach to unveil the structure–property relationship that could provide some general rules in rational design of PTAs, and paves the way for a next generation of supramolecular medicine for photothermal theranostics.