Neuroimage of voluntary movement: Topography of the Bereitschaftspotential, a 64-channel DC current source density study
Neuroimage of voluntary movement: Topography of the Bereitschaftspotential, a 64-channel DC current source density study
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DOI：
10.1006/nimg.1998.0388
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发表时间：
1999-01-01
期刊：
影响因子：
5.7
通讯作者：
Deecke, L
中科院分区：
文献类型：
--
作者：
Cui, RQ;Huter, D;Deecke, L
本文对17名健康受试者在56个头皮位置进行右手食指快速伸指时的Bereitschaftspotential（BP）进行了记录。这项研究的目的是促进我们对BP的生理基础的理解，特别是要说明BP发作时的情况。为此，在运动开始前2.51 s开始的短时间间隔（35和/或70 ms）内分析BP的空间模式。对于每个时间段，通过使用样条插值计算BP的球形模型。然后将头皮表面电位的空间分布转化为电流源密度的空间分布（CSD图）。BP的发作时间和初始CSD活动的发作时间在运动开始前的2.23和1.81秒之间。我们选择了一个时间窗口之间的1.6和1.5秒的运动开始前，以分析在每个主题的空间CSD模式。在10名受试者中，在初级运动皮层（MI：电极位置C3、CP3和CP5）上没有显著电流汇的情况下，位于内侧壁运动区（SMA前、SMA固有和前扣带皮层：电极位置C1、C2、FCz、Ct）上方的头皮区域中存在显著电流汇。在三个受试者中，在两个部位都存在显著的电流汇，而在另外三个受试者中，仅在外侧运动皮层上观察到电流汇。在一个受试者中，没有测量到显著的电流吸收。得出的结论是，有一个大组的主题（13/17），其中BP在发病与电流汇在内侧壁运动区。在较晚的时间间隔（0.6至0.5秒前的运动开始），显着的电流汇被发现在13名受试者在内侧和10名受试者在外侧记录。这些数据被认为是一致的假设，至少在大多数受试者，内侧壁运动区被激活早于横向运动区时，组织启动一个简单的自主节奏的运动。表面记录的脑电图不允许进一步规范的皮质区，这有助于电流汇。但是，在非人类灵长类动物的电生理学和人类脑成像的当前文献的背景下，有人建议，SMA和前扣带皮层有助于电流汇，额中央中线，以及初级运动皮层（MI）有助于头皮区域的电流汇，这是位于MI上方，并密切落后于它（C）1999年学术出版社。
The Bereitschaftspotential (BP) was recorded at 56 scalp positions when 17 healthy subjects performed brisk extensions of the right index finger. Aim of the study was to contribute to our understanding of the physiology underlying the BP and, in particular, to specify the situation at BP onset. For this purpose, the spatial pattern of the BP was analyzed in short time intervals (35 and/or 70 ms) starting 2.51 s before movement onset. For each time segment a spherical model of the BP was calculated by using spline interpolation. Then the spatial distribution of the electric potential at the scalp surface was transformed into a spatial distribution of current source densities (CSD map). Onset times of the BP and onset times of initial CSD-activity ranged between 2.23 and 1.81 s before movement onset. We selected a time window between 1.6 and 1.5 s before movement onset in order to analyze the spatial CSD pattern in each subject. In 10 subjects there was a significant current sink in the scalp area located over medial-wall motor areas (pre-SMA, SMA proper and anterior cingulate cortex: electrode positions C1, C2, FCz, Ct) in the absence of a significant current sink over the primary motor cortex (MI: electrode positions C3, CP3, and CP5). in three subjects significant current sinks were present at both sites and in another three subjects a current sink only over the lateral motor cortex was observed. In one subject no significant current sinks were measured. It is concluded that there is a large group of subjects (13/17) in whom BP at onset is associated with a current sink over medial-wall motor areas. At a later time interval (0.6 to 0.5 s before movement onset), significant current sinks were found in 13 subjects in medial and in 10 subjects in lateral recordings. These data were considered to be consistent with the hypothesis that, at least in a majority of subjects, medial-wall motor areas are activated earlier than lateral motor areas when organizing the initiation of a simple self-paced movement. Surface-recordings of the EEG do not allow further specification of cortical areas, which contribute to the current sinks. But in context with the current literature of the electrophysiology of nonhuman primates and of brain imaging in humans it is suggested that SMA and anterior cingulate cortex contribute to the current sink, the fronto-central midline, and that the primary motor cortex (MI) contributes to the current sink in the scalp area, which is located above MI and closely posterior to it. (C) 1999 Academic Press.