Balancing Expectations for Success in Stem Cell-Based Clinical Trials for Parkinson's Disease.
Balancing Expectations for Success in Stem Cell-Based Clinical Trials for Parkinson's Disease.
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DOI：
10.1016/j.stem.2020.09.002
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发表时间：
2020-10
期刊：
影响因子：
23.9
通讯作者：
O. Lindvall
中科院分区：
文献类型：
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作者：
O. Lindvall
即将进行的评估干细胞衍生的多巴胺能神经元移植到帕金森病患者纹状体中的临床试验可能会在人脑神经元替代方面产生突破性的结果。然而，正如这里所强调的，这种多系统疾病的临床竞争性治疗之路可能是漫长而曲折的。
Upcoming clinical trials assessing transplantation of stem cell-derived dopaminergic neurons into the striatum in patients with Parkinson's disease could generate groundbreaking results on neuronal replacement in the human brain. However, as highlighted here, the road toward a clinically competitive treatment for this multisystem disorder will probably be long and winding.